731-84-0

Upstream product

• 525-76-8 2-methyl-4-oxo-3,1-benzoxazine 
• 392-83-6 o-trifluoromethylphenyl bromide 
• 271-58-9 anthranil 

Downstream Products

• 851-70-7 2-amino-2'-<-(trifluoromethyl)benzoyl>acetanilide 
• 81100-93-8 2-oxo-5-(2-trifluoromethylphenyl)-1,2,3,5-tetrahydro[4,1]-benzoxazepine 
• 81100-98-3 2-thioxo-5-(2-trifluoromethylphenyl)-1,2,3,5-tetrahydro[4.1]-benzoxazepine 
• 1581699-78-6 C₃₉H₃₀F₃N₃O₅Pd 
• 1581699-74-2 C₃₈H₃₀F₃N₃O₄ 
• 1581699-75-3 C₃₉H₃₂F₃N₃O₅ 
• 1581699-76-4 C₃₈H₂₈F₃N₃NiO₄ 
• 1581699-77-5 C₃₉H₃₀F₃N₃NiO₅ 

Relevant academic research and scientific papers

Reactivity of 2,1-Benzisoxazole in Palladium-Catalyzed Direct Arylation with Aryl Bromides

The Pd-catalyzed direct arylation of 2,1-benzisoxazole with aryl bromides to access 3-arylbenzoisoxazoles proceeds in moderate-to-high yields with 1 mol % Pd(OAc)2 or 2 mol % PdCl(C3H5)(dppb) (dppb=1,4-bis(diphenylphosphino)butane) as the catalysts and KOAc as an inexpensive base. A wide variety of (hetero)aryl bromides have been employed successfully. Moreover, arylations followed by benzisoxazole ring opening allowed the preparation of 2-aminobenzophenones in only two steps. What a couple: The Pd-catalyzed direct arylation of 2,1-benzisoxazole with aryl bromides and 1 mol % of phosphine-free Pd(OAc)2 catalyst in association with KOAc as an inexpensive base allows the preparation of 3-arylbenzoisoxazoles in moderate-to-high yields. Moreover, the 2,1-benzisoxazole C-3-arylations followed by benzisoxazole ring opening gives access to 2-aminobenzophenones in only two steps.