73100-69-3Relevant academic research and scientific papers
Synthesis of potential inhibitors of hypoxanthine-guanine phosphoribosyltransferase for testing as antiprotozoal agents. I. 7-Substituted 6-oxopurines
Piper,Laseter,Montgomery
, p. 357 - 364 (2007/10/02)
Biological evidence indicates that the enzyme hypoxanthine-guanine phosphoribosyltransferase (HGPRTase) (EC 2.4.2.8) is vital for cell proliferation in malarial parasites but nonessential for mammalian cells. 7-Substituted guanines and hypoxanthines in wh
