73110-49-3

Usage

Uses

Used in Pharmaceutical Applications:
1-(2-HYDROXYPHENYL)-3-(4-ISOPROPYLPHENYL)PROP-2-EN-1-ONE is used as a therapeutic agent for its potential in treating various conditions such as cancer, diabetes, and neurodegenerative diseases. Its antioxidant and anti-inflammatory properties contribute to its potential health and wellness benefits.
Used in Skincare and Cosmetics Industry:
1-(2-HYDROXYPHENYL)-3-(4-ISOPROPYLPHENYL)PROP-2-EN-1-ONE is used as an ingredient in skincare and cosmetic products for its anti-aging and skin-brightening effects, enhancing the overall appearance and health of the skin.

Upstream product

• 118-93-4 o-hydroxyacetophenone 
• 122-03-2 (4-isopropylbenzaldehyde) 

Downstream Products

• 92831-11-3 2-[4-(1-methylethyl)phenyl]-4H-1-benzopyran-4-one 

Relevant academic research and scientific papers

Synthesis, molecular properties, anti-inflammatory and anticancer activities of novel 3-hydroxyflavone derivatives

A new series of 3-hydroxyflavones (1–46) were synthesized according to the Claisen-Schmidt followed by Algar-Flynn-Oyamada reactions (AFO) in one step. The synthesized flavonoids were characterized by 1H NMR, 13C NMR and DCI-HRMS. All the synthesized compounds were tested in vitro for their 15-lipoxygenase inhibitory and cytotoxic activity against the human cell lines HCT-116 (Human colon carcinoma), IGROV-1 and OVCAR-3 (human ovarian carcinoma). It has been found that the derivatives 25, 37 and 45 were the most actives against HCT-116 (IC50 = 8.0, 9.0 and 9.0 μM, respectively) and against IGROV-1 (IC50 = 2.4, 5.0 and 6.0 μM, respectively). The derivatives 14 and 21 exhibited the higher anti-inflammatory activity at 100 μM with PI values of 76.50 and 72.70%, respectively. Molecule description was performed with DFT calculations, the drug likeness and bioactivity scores. The results exhibted that some compounds are in linear correlation with Lipinski's rule of five showing good drug likeness and bioactivity score for drug targets.

Ionic liquid mediated Cu-catalyzed cascade oxa-Michael-oxidation: Efficient synthesis of flavones under mild reaction conditions

Flavonoids are a class of natural products, found in a wide range of vascular plants and dietary components. Their low toxicity and extensive biological activities, including anti-cancer and anti-bacterial, have made them attractive candidates to serve as therapeutic agents for many diseases. Herein, we disclose a highly efficient synthetic method of CuI-catalyzed cascade oxa-Michael-oxidation, using chalcones as substrates, mediated by the ionic liquid [bmim][NTf2] at a low temperature. This efficient synthetic method has demonstrated high synthetic utility and can afford flavones in good to high yields (up to 98%).