73124-23-9Relevant academic research and scientific papers
Chemoselective Reduction of Azlactones Using Schwartz's Reagent
Pinheiro, Danielle L. J.,ávila, Eloah P.,Batista, Gabriel M. F.,Amarante, Giovanni W.
, p. 5981 - 5985 (2017)
Highly chemoselective addition of Schwartz's reagent to widely available azlactones is described. This method allows the preparation of challenged functionalized α-amino aldehydes, in good to high isolated yields at room temperature, after only 2 min reaction. The presence of sensitive functionalities or electronic factors does not compromise the potential of the method. The use of an excess of the reducing reagent gave a very functionalized allylic alcohol derivative in 86% yield.
