73128-92-4Relevant academic research and scientific papers
MODULATORS OF HSD17B13 AND METHODS OF USE THEREOF
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, (2021/01/23)
The disclosure relates to compounds and pharmaceutical compositions capable of modulating the hydroxysteroid 17-beta dehydrogenase (HSD17B) family member proteins including inhibiting the HSD17B member proteins, e.g. HSD17B13. The disclosure further relates to methods of treating liver diseases, disorders, or conditions with the compounds and pharmaceutical compositions disclosed herein, in which the HSD17B family member protein plays a role.
Synthesis of s-pixyl derivatives for mass spectrometric applications
Khan, Safraz,Bernad, Pablo L.,Korshun, Vladimir A.,Southern, Edwin M.,Shchepinov, Mikhail S.
, p. 2453 - 2456 (2007/10/03)
Synthesis of novel S-pixyls based on the thioxanthyl skeleton is described. Thioxanthone derivatives were prepared by a regioselective intramolecular Friedel-Crafts acylation reaction and converted into S-pixyl derivatives by Grignard synthesis. S-Pixyl carbocations stabilised by electron donating groups on the thioxanthyl backbone produced exceptional mass spectra under (MA)LDI conditions (laser desorption ionisation, both with and without matrix), and can be detected down to femtomol levels. Georg Thieme Verlag Stuttgart.
