73129-86-9Relevant academic research and scientific papers
Synthesis and pharmacological studies of some phthalimidoxy substituted spiro-thiazolidinone derivatives of isatin
Bhambi, Dinesh,Sharma, Chirag,Sharma, Shweta,Salvi, Vijay Kumar,Talesara
experimental part, p. 1006 - 1012 (2009/12/30)
Novel spiro-isatin-thiazolidino-pyrazoline compounds containing alkoxyphthalimide moiety have been synthesized through a four step pathway starting from chalcone 1a-e. Cyclization of these with hydrazine hydrate in absolute ethanol have yielded l-acetyl-3-(4-aminophenyl)-5-(4-substituted phenyl)-2-pyrazoline 2a-e. Acid catalyzed condensation of 2a-e with isatin 3 has yielded 3-[4-{l-acetyl-5-(4-substituted phenyl)-2-pyrazoIine-3-yl}phenylimino] indole-2-one 4a-e. These Schiff bases on reaction with mercaptoacetic acid in presence of anhydrous ZnCI2 gave their corresponding spirothiazolidinone derivatives 5a-e. Subsequent treatment with bromoethoxyphthalimide yielded titled compounds 3'-{4-(lacetyl-5-(4-substituted phenyl)-2-pyrazoline-3-yl)phenyl}-l-Af-ethoxyphthalimido-4'//-spiro[indole-3,2, -[l,3]thiazolidene]2,4'-l H-dione 6a-e.
