73140-31-5Relevant academic research and scientific papers
Preparation of pyrazine carboxamides: A reaction involving N-heterocyclic carbene (NHC) intermediates
Naredla, Rajasekhar Reddy,Dash, Barada P.,Klumpp, Douglas A.
supporting information, p. 4806 - 4809 (2013/10/08)
In the reactions of 2,3-pyrazinedicarboxylic anhydride with amines and anilines, pyrazine carboxamides are formed in good to excellent yields. A mechanism is proposed involving ring opening of the anhydride and decarboxylation of the heterocyclic ring. Based on other similar heterocyclic decarboxylations, this suggests the involvement of an N-heterocyclic carbene intermediate leading to the product.
