73148-42-2Relevant academic research and scientific papers
Diastereoselective syntheses of 3-aryl-5-(arylalkyl)-6-methyl-1-(1- phenylethyl)thioxotetrahydropyrimidin-4(1H)-ones: A stereochemical perspective from endo and exocyclic chiral centres
Kumar, Varun,Raghavaiah, Pallepogu,Mobin, Shaikh M.,Nair, Vipin A.
experimental part, p. 4960 - 4970 (2010/11/17)
Diastereoselective syntheses of 3-aryl-(S/R)-6-methyl-1-[(S/R)-1- phenylethyl)]-2-thioxotetrahydro pyrimidin-4(1H)-ones were achieved in good yields by the condensation of aryl isothiocyanates with ethyl 3-(1-phenylethylamino)butanoate in a one-pot reaction. Benzylation of these substrates illustrated that the orientations of the exocylic and endocylic groups determine the stereochemical outcome of the product formed.
Efficient synthesis of β-aminoacrylates and β-enaminones catalyzed by Zn(OAc)2·2H2O
Vohra, Ramandeep Kaur,Renaud, Jean-Luc,Bruneau, Christian
, p. 1943 - 1952 (2007/10/03)
The direct condensation of amines with β-ketoesters and β-diketones to produce functional enamine derivatives has been investigated with zinc Lewis acid catalysts. Zn(OAc)2·2H2O shows good catalytic activity and leads to a chemo- and stereoselective formation of (Z)-enamine derivatives from aliphatic primary amines and ring-substituted anilines under mild conditions.
