73159-07-6

Upstream product

• 132883-18-2 methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-D-glycero-β-D-galacto-non-2-ulopyranosyl chloride 
• 107-18-6 allyl alcohol 

Downstream Products

• 325962-13-8 3-benzylthiopropyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-α-D-glycero-D-galacto-2-nonulopyranosonic acid metyl ester 
• 114474-54-3 C₄₂H₅₈N₂O₂₁ 
• 114474-54-3 C₄₂H₅₈N₂O₂₁ 
• 114474-52-1 (2R,4S,5R,6R)-5-Acetylamino-2-allyloxy-6-[(S)-benzyloxy-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-methyl]-4-hydroxy-tetrahydro-pyran-2-carboxylic acid methyl ester 
• 114474-53-2 (2R,4S,5R,6R)-5-Acetylamino-2-allyloxy-6-((1R,2R)-1-benzyloxy-2,3-dihydroxy-propyl)-4-hydroxy-tetrahydro-pyran-2-carboxylic acid methyl ester 
• 152957-11-4 methyl 5-acetamido-2-<5''-(methyl 2',3'-di-O-benzoyl-6'-deoxy-β-L-galactopyranoside-4'-yl)-4''-oxo-pent-1''-yl>-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulosonate 
• 325962-14-9 3-benzylthiopropyl 5-acetamido-3,5-dideoxy-α-D-glycero-D-galacto-2-nonulopyranosonic acid methyl ester 

Relevant academic research and scientific papers

Synthesis of novel mimetics of CMP-sialic acid as the inhibitors of sialyltransferases

Novel mimetics of CMP-sialic acid were designed as the inhibitors of sialyltransferases. They were synthesized in a short step from a cytosine carrying β-hydroxy-α-L-amino acid based on the knowledge that nikkomycin, a peptidic derivative of an uracil carrying amino acid, shows a potent inhibitory activity toward N-acetyl-D-glucosaminyltransferases that employ UDP-N-acetyl-D-glucosamine as the donor substrate. The cytosine carrying β-hydroxyl-α-L-amino acid, a key intermediate in our synthetic strategy, was easily prepared by the L-threonine aldolase (LTA) catalyzed reaction.