73161-19-0Relevant academic research and scientific papers
Substituted benzothieno [2,3-c] tetrahydropyridine derivative and preparation method and application thereof
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Paragraph 0054, (2018/07/30)
The invention belongs to the technical field of medicinal chemistry and medicines, and relates to a substituted benzothieno [2,3-c] tetrahydropyridine derivative as shown in formula (I), a preparationmethod of the substituted benzothieno [2,3-c] tetrahydr
Discovery of novel 1,2,3,4-tetrahydrobenzo[4, 5]thieno[2, 3-c]pyridine derivatives as potent and selective CYP17 inhibitors
Wang, Mingliang,Fang, Yanjia,Gu, Shoulai,Chen, Fangfang,Zhu, Zhengjiang,Sun, Xun,Zhu, Jidong
, p. 157 - 172 (2017/03/31)
The inhibition of CYP17 to block androgen biosynthesis is a well validated strategy for the treatment of prostate cancer. Herein we reported the design, synthesis and structure–activity relationship (SAR) study for a series of novel 1,2,3,4- tetrahydroben
PIPERAZINYL OXOALKYL TETRAHYDRO-BETA-CARBOLINES AND RELATED ANALOGUES
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Page/Page column 68, (2009/03/07)
Piperazinyl oxoalkyl tetrahydro-beta-carbolines and related analogues of the formula (I): are provided, as are methods for their preparation and use. Such compounds may generally be used to modulate ligand binding to histamine H3 receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and therapeutic methods are provided, as are methods for using such ligands for detecting histamine H3 receptors (e.g., receptor localization studies).
FUSED HETEROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF HISTONE DEACETYLASE
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Page/Page column 170-172, (2008/06/13)
Disclosed are compounds of formula (I) that inhibit histone deacetylase (HDAC) enzymatic activity, pharmaceutical compositions comprising such compounds, as well as methods to treat conditions, particularly proliferative conditions, mediated at least in part by HDAC, wherein A, W, W1, W2, Ar2, and G are described herein.
