73162-96-6

Usage

Uses

Used in Pest Control Industry:
Milbemycin b, 5-O-demethyl-28-deoxy-5-O-[(1,1-dimethylethyl)dimethylsi lyl]-6,28-epoxy-13-hydroxy-25-(1-methylpropyl)-, [6R,13S,25R(S)]is used as an intermediate in the synthesis of Milbemycin D for its nematocidal and insecticidal properties. This allows for the development of effective treatments against various pests, including nematodes and insects, which can be detrimental to agriculture and the environment.

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 73162-95-5 ivermectin aglycone 
• 71827-03-7 5-O-demethyl-22,23-dihydro-avermectin A₁a 

Downstream Products

• 117755-73-4 5-O-(tert-butyldimethylsilyl)-13-O-(p-toluenesulfonyl)-22,23-dihydroavermectin B₁ aglycon 
• 1258313-40-4 C₄₁H₅₅NO₉ 
• 1258313-42-6 C₄₁H₅₄ClNO₉ 
• 1258313-44-8 C₄₁H₅₄ClNO₉ 
• 1258313-45-9 C₄₂H₅₇NO₉ 

Relevant academic research and scientific papers

Practical Syntheses of 13-O-[(2-Methoxyethoxy)methyl]-22,23-dihydroavermectin B1 Aglycon [Dimedectin Isopropanol, MK-324] and 13-epi-O-(Methoxymethyl)-22,23-dihydroavermectin B1 Aglycon [L-694,554], Flea Active Ivermectin Analogues

Practical high yielding syntheses of 13-O-[(2-methoxyethoxy)methyl]-22,23-dihydroavermectin B1 aglycon (dimedectin 2-propanol, MK-324, 1) and 13-epi-O-(methoxymethyl)-22,23-dihydroavermectin B1 aglycon (L-694,554, 2), both potent flea insecticides, from ivermectin are presented. The successful selective manipulation of silyl protecting groups on ivermectin aglycon led to the facile preparation of 5,7-O-bis-silyl-22,23-dihydroavermectin B1 aglycon 7 as the key intermediate for the large scale syntheses of these compounds. Development of a dual pyridine/tertiary amine system for mesylation of the C-13α hydroxyl group of 7 and subsequent displacement with cesium propionate-propionic acid led to the successful inversion of the 13-hydroxy group.

A milbemycin analogs and method for preparation thereof and use in pesticide

The invention discloses milbemycins analogues as well as a preparation method and application thereof in pesticides. The new milbemycins analogues have the following structural formula shown the specification, wherein R1 is 2-naphthyl, p-methylphenyl, met

Synthesis analogues of milbemycin and their bioactivity evaluation

Eight new 13-O-aminocarbonylivermectin aglycones and 4′-O-aminocarbonylivermectin monosaccharide were synthesized from ivermectin aglycone and ivermectin monosaccharide by the selective protection of C5-OH group. Their bioactivities were evalua