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InChI:InChI=1/C51H72N14O12S2/c52-39(67)18-17-33-44(72)63-36(25-40(53)68)47(75)64-37(49(77)65-22-8-12-38(65)48(76)61-32(11-7-21-57-50(55)56)43(71)58-27-41(54)69)28-78-79-51(19-5-2-6-20-51)26-42(70)59-34(24-30-13-15-31(66)16-14-30)45(73)62-35(46(74)60-33)23-29-9-3-1-4-10-29/h1,3-4,9-10,13-16,32-38,66H,2,5-8,11-12,17-28H2,(H2,52,67)(H2,53,68)(H2,54,69)(H,58,71)(H,59,70)(H,60,74)(H,61,76)(H,62,73)(H,63,72)(H,64,75)(H4,55,56,57)/t32?,33-,34-,35+,36-,37+,38-/m0/s1

Relevant academic research and scientific papers

arginine-vasopressin and arginine-vasopressin, Two Highly Potent Antagonists of the Vasopressor Response to Arginine-vasopressin

As part of our studies on the design synthesis of antagonists of the vasopressor response to arginine-vasopressin (AVP), we have syntheiszed arginine-vasopressin (in duplicate) and arginine-vasopressin .The required protected intermediate for 1 was synthesized by (a) a combination of solid-phase synthesis and an 8 + 1 coupling in solution and (b) entirely by solid-phase synthesis.The required protected precursor for 2 was synthesized entirely by solid-phase methods. 1 and 2 were tested for agonistic and antagonistic activities in rat vasopressor, rat antidiuretic, and rat uterus assay systems. d(CH2)5Tyr(Me)AVP exhibits a surprisingly potent and prolonged antivasopressor effect.It has an antivasopressor pA2 of 8.62 +/- 0.03 and an antidiuretic potency of 0.31 +/- 0.07 unit/mg.Material from the second synthesis of d(CH2)5Tyr(Me)AVP has a pA2 value of 8.67 +/- 0.02. d(CH2)5AVP also exhibited a potent, althhough less prolonged, antivasopressor effect.It has an antivasopressor pA2 of 8.35 +/- 0.09 and an antidiuretic potency of only 0.033 +/- 0.005 unit/mg.These are the two most potent vasopressor antagonists reported to date.Both analogues also antagonize the actions of oxytocin on the rat uterus (a) in the absence of Mg2+, (b) in the presence of 0.5 mM Mg2+, and (c) in situ.They exhibit, respectively, the following pA2 values in each of the assay systems a-c: (1) a, 8.13 +/- 0.12; b, 7,24 +/- 0.07; c, 6.62 +/- 0.07; (2) a, 8.15 +/- 0.20; b, 7.19 +/- 0.08; c, 6.79 +/- 0.19.With their potent ability to antagonize the vasopressor effects of AVP, d(CH2)5Tyr(Me)AVP and d(CH2)5AVP should be valuable additions to our previously reported antagonists for use as pharmacological tools with which to probe the possible role(s) of AVP in cardiovascular regulation in normal and pathophysicological states.