73177-35-2

Basic information

• Product Name: 2-Methyl-4-azaindole
• Synonyms: 2-Methyl-1H-pyrrolo[3,2-b]pyridine;1H-Pyrrolo[3,2-b]pyridine, 2-Methyl-;2-Methyl-4-azaindole
• CAS NO: 73177-35-2
• Molecular Formula: C₈H₈N₂
• Molecular Weight: 132.16252
• Product Categories: Amines;Heterocycles;Indole Derivatives;Intermediates & Fine Chemicals;Pharmaceuticals;Heterocycle-Pyridine series
• Mol File: 73177-35-2.mol
• Article Data: 2

Chemical Properties

• Melting Point: 193-194 °C
• Boiling Point: 282.824°C at 760 mmHg
• Flash Point: 126.04°C
• Appearance: /
• Density: 1.187g/cm³
• Vapor Pressure: 0.006mmHg at 25°C
• Refractive Index: 1.667
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 15.23±0.40(Predicted)
• CAS DataBase Reference: 2-Methyl-4-azaindole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methyl-4-azaindole(73177-35-2)
• EPA Substance Registry System: 2-Methyl-4-azaindole(73177-35-2)

Safety Data

• Hazardous Substances Data: 73177-35-2(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 73177-35-2 differently. You can refer to the following data:
1. 2-Methyl-4-azaindole is an intermediate used for the synthesis of pyrrolo[3,2-b]pyridinylalkyl benzamide derivatives as platelet aggregation inhibitors.
2. An intermediate used for the synthesis of pyrrolo[3,2-b]pyridinylalkyl benzamide derivatives as platelet aggregation inhibitors.

Synthesis Reference(s)

The Journal of Organic Chemistry, 45, p. 1546, 1980 DOI: 10.1021/jo01296a052

InChI:InChI=1/C8H8N2/c1-6-5-8-7(10-6)3-2-4-9-8/h2-5,10H,1H3

Upstream product

• 56983-98-3 (2-pyridyl)acetaldoxime 

Downstream Products

• 219762-88-6 3-((2,4-dichlorophenyl)hydroxymethyl)-2-methylpyrrolo[3,2-b]pyridine 
• 219762-89-7 3-(2,4-dichlorobenzyl)-2-methylpyrrolo[3,2-b]pyridine 
• 1383924-41-1 1-(4-chlorobenzyl)-2-methyl-1H-pyrrolo[3,2-b]pyridine 
• 1383922-54-0 2-(1-(4-chlorobenzyl)-2-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)-N-(2-methoxypyridin-4-yl)-2-oxoacetamide 
• 1383924-42-2 2-(1-(4-chlorobenzyl)-2-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)-2-oxoacetic acid 
• 219762-87-5 3-(2,4-dichlorobenzoyl)-2-methylpyrrolo[3,2-b]pyridine 

Relevant articles and documents

Hypervalent Fluoroiodane-Triggered Synthesis of Fluoro-Azabenzoxazepines and Azaindoles

Fluorination reactions facilitated by hypervalent F-iodanes have experienced vivid attention recently, since they often lead to novel, fluorinated scaffolds not accessible with common electrophilic fluorination reagents. The fluorocyclization of styrenes equipped with an amide functionality in the ortho position using F-iodanes represents a transformation with unusual chemoselectivity. Within this context, the conversion of pyridine derivatives to fluoropyridyloxazepines, which constitutes a particular challenge due to the deactivating properties of the aza heterocycle, was accomplished in this work using the bench-stable λ3-F-benzoiodoxole under Lewis acid catalysis. The versatility of the obtained F-heterocycles as building blocks in organic synthesis was demonstrated by their straightforward conversion into azaindoles in a one-pot, three-step reaction sequence.