731815-55-7

Upstream product

• 2213-63-0 2,3-dichloroquinoxaline 
• 121-52-8 3-nitrophenylsulfonamide 

Downstream Products

• 934528-15-1 N-(3-((2-chloro-5-methoxyphenyl)amino)quinoxalin-2-yl)-3-nitrobenzenesulfonamide 
• 1433222-74-2 3-amino-N-{3-[(2-chloro-5-methoxyphenyl)amino]quinoxalin-2-yl}benzenesulfonamide hydrochloride 
• 934526-89-3 N-(3-{[(2Z)-3-[(2-chloro-5-methoxyphenyl)amino]quinoxalin-2(1H)-ylidene]sulfamoyl}phenyl)-2-methylalaninamide 
• 934526-57-5 3-amino-N-(3-(3-amino-5-methoxy-phenylamino)quinoxalin-2-yl)benzenesulfonamide 
• 934530-41-3 N-(3-(N-(3-(3,5-dimethoxy-phenylamino)quinoxalin-2-yl)sulfamoyl)phenyl)azetidine-3-carboxamide 
• 934528-18-4 N-(3-(2,6-dichloropyridin-4-ylamino)quinoxalin-2-yl)-3-nitrobenzenesulfonamide 
• 934527-94-3 N-(3-(3-methoxy-5-nitrophenylamino)quinoxalin-2-yl)-3-nitro-benzenesulfonamide 
• 934526-42-8 N-(3-(3,5-dimethoxyphenylamino)quinoxalin-2-yl)-3-nitrobenzenesulfonamide 

Relevant academic research and scientific papers

Phosphatidylinositol 3-Kinase Inhibitors for the Treatment of Lymphoproliferative Malignancies

Methods are provided for treating a lymphoproliferative malignancy to a patient in need of such treatment, comprising administering to the patient an effective amount of compound A as described herein.

CRYSTALLINE COMPOUNDS

Provided herein are polymorph E, a mixed DMAC/toluene solvate and a DMSO solvate of N-(3-{[(2Z)-3-[(2-chloro-5- methoxyphenyl)amino]quinoxalin-2(1H)-ylidene]sulfamoyl}phenyl)-2- methylalaninamide.

TABLET FORMULATION OF A PHOSPHATIDYLINOSITOL 3-KINASE INHIBITOR

Methods are provided for treating cancer to a patient in need of such treatment, comprising administering a PI3K inhibitor.

COMPOUNDS FOR USE IN THE TREATMENT OF BASAL CELL CARCINOMA

The invention provides a method for treating BCC in a patient in need of such treatment, comprising administering a therapeutically effective amount a compound of formula Ila.

PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS FOR THE TREATMENT OF CANCER

The invention provides a method for treating endometrial carcinoma comprising administering a Compound of Formula (I) or (II). Also provided is a method for treating breast cancer, comprising administering letrozole in combination with either a Compound o

PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS FOR THE TREATMENT OF CHILDHOOD CANCERS

The invention provides a method for treating childhood cancers, including acute lymphocytic leukemia, neuroblastoma, and rhabdomyosarcoma, comprising administering a compound of Formula (I) to a patient in need of such treatment.

N- (3- { [ (3- { [2-CHLORO-5- (METHOXY) PHENYL] AMINO} QUINOXALIN- 2 -YL) AMINO] SULFONYL} PHE NYL) - 2 -METHYLALANINAMIDE AS PHOSPHATIDYLINOSITOL 3 - KINASE INHIBITOR FOR THE TREATMENT OF LYMPHOPROLIFERATIVE MALIGNANCIES

Methods are provided for treating a lymphoproliferative malignancy to a patient in need of such treatment, comprising administering to the patient an effective amount of compoud A as described herein.

METHODS OF USING PI3K AND MEK MODULATORS

The invention provides methods of treating cancer with a combination of compounds which inhibit kinases, more specifically MEK and PI3K.

METHODS OF TREATING BY INHIBITING WITH QUINAXOLINE INHIBITORS OF PI3K-ALPHA

The present invention provides methods of treating cancer by administering a compound of Formula I, optionally as a pharmaceutically acceptable salt, solvate and/or hydrate thereof, in combination with other cancer treatments.

PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS AND METHODS OF THEIR USE

The present invention comprises small molecule inhibitors of phosphatidylinositol 3-kinase (PI3K), which is associated with a number of malignancies such as ovarian cancer, cervical cancer, breast cancer, colon cancer, rectal cancer, and glioblastomas, am