731855-54-2

Upstream product

• 43028-74-6 ethyl 2-amino-5-cyano-4-methyl-3-thiophenecarboxylate 
• 874-90-8 4-methoxybenzonitrile 

Downstream Products

• 1628755-44-1 C₁₅H₁₀ClN₃OS 
• 731855-90-6 2-(4-methoxyphenyl)-5-methyl-4-morpholin-4-ylthieno[2,3-d]pyrimidine-6-carbonitrile 
• 731855-76-8 2-(4-methoxyphenyl)-5-methyl-4-(4-methylpiperazin-1-yl)thieno[2,3-d]pyrimidine-6-carbonitrile 
• 1611471-60-3 4-(4-benzylpiperazin-1-yl)-2-(4-methoxyphenyl)-5-methylthieno[2,3-d]pyrimidine-6-carbonitrile 
• 731855-89-3 4-dimethylamino-2-(4-methoxyphenyl)-5-methylthieno[2,3-d]pyrimidine-6-carbonitrile 
• 731855-77-9 4-diethylamino-2-(4-methoxyphenyl)-5-methylthieno[2,3-d]pyrimidine-6-carbonitrile 
• 731855-78-0 2-(4-methoxyphenyl)-5-methyl-4-pyrrolidin-1-ylthieno[2,3-d]pyrimidine-6-carbonitrile 

Relevant academic research and scientific papers

Microwave-assisted synthesis of potent PDE7 inhibitors containing a thienopyrimidin-4-amine scaffold

A series of novel thienopyrimidin-4-amines have been synthesized and evaluated as phosphodiesterase (PDE) inhibitors. A rationale for the observed selectivity against PDE7 has been obtained from molecular modelling studies on the most active compounds. This journal is the Partner Organisations 2014.

4-AMINOTHIENO[2,3-d]PYRIMIDINE-6-CARBONITRILE DERIVATIVES AS PDE7 INHIBITORS

New 4-aminothieno[2,3-d]pyrimidine-6-carbonitrile derivatives having the chemical structure of general formula (I), and pharmaceutically acceptable salts thereof are disclosed as well as processes for their preparation and to pharmaceutical compositions c