73196-87-9 Usage
Uses
Used in Organic Synthesis:
2',3',5'-TRI-O-ACETYL-2N,2N-DIMETHYL-GUANOSINE is used as a key intermediate in organic synthesis for the development of various chemical compounds. Its unique structure allows it to serve as a building block or a modifying agent in the synthesis of complex organic molecules, including pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2',3',5'-TRI-O-ACETYL-2N,2N-DIMETHYL-GUANOSINE is utilized as a precursor or a synthetic intermediate for the production of innovative drug molecules. Its specific chemical properties enable the creation of new therapeutic agents with potential applications in treating various diseases and medical conditions.
Used in Research and Development:
2',3',5'-TRI-O-ACETYL-2N,2N-DIMETHYL-GUANOSINE is also employed in research and development settings, where it is used to explore new chemical reactions, investigate the properties of novel compounds, and develop new synthetic methodologies. Its unique structure and reactivity make it a valuable tool for advancing the understanding of organic chemistry and its applications.
Check Digit Verification of cas no
The CAS Registry Mumber 73196-87-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,3,1,9 and 6 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 73196-87:
(7*7)+(6*3)+(5*1)+(4*9)+(3*6)+(2*8)+(1*7)=149
149 % 10 = 9
So 73196-87-9 is a valid CAS Registry Number.
73196-87-9Relevant academic research and scientific papers
Chemical synthesis of a 5′-terminal TMG-capped triribonucleotide m32,2,7G5′ pppAmpUmpA of U1 RNA
Sekine, Mitsuo,Kadokura, Michinori,Satoh, Takahiko,Seio, Kohji,Wada, Takeshi,Fischer, Utz,Sumpter, Vicki,Lührmann, Reinhard
, p. 4412 - 4422 (2007/10/03)
The 5′-terminal TMG-capped triribonucleotide, m32,2,7G5′pppAmpUmpA, has been synthesized by condensation of an appropriately protected triribonucleotide derivative of ppAmpUmpA with a new TMG-capping reagent. During this total synthesis, it was found that the regioselective 2′-O-methylation of 3′,5′-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-N-(4- monomethoxytrityl)adenosine was achieved by use of MeI/Ag2O without affecting the base moiety. A new route to 2-N,2-N-dimethylguanosine from guanosine via a three-step reaction has also been developed by reductive methylation using paraformaldehyde and sodium cyanoborohydride. These key intermediates were used as starting materials for the construction of a fully protected derivative of pAmpUmpA and a TMG-capping reagent of Im-pm32,2,7G. The target TMG-capped tetramer, m32,2,7G5′ pppAmpUmpA, was synthesized by condensation of a partially protected triribonucleotide 5′-terminal diphosphate species, ppAMMTrmpUmpA, with Im-pm32,2,7G followed by treatment with 80% acetic acid. The structure of m32,2,7G5′ pppAmpUmpA was characterized by 1H and 31P NMR spectroscopy as well as enzymatic assay using snake venom phosphodiesterase, calf intestinal phosphatase, and nuclease P1.
