73198-49-9Relevant academic research and scientific papers
Multicomponent radical processes: Synthesis of substituted piperidinones
Godineau, Edouard,Landais, Yannick
, p. 12662 - 12663 (2007)
Three and four-component radical and radical-organometallic processes have been developed that provide a simple access to 2,3-disubstituted piperidinones. Reasonable yield and high stereoselectivities were achieved in a number of cases with three C-C bond
Intermolecular addition of alkyl radicals to imines in the absence and in the presence of a Lewis acid
Halland,Jorgensen
, p. 1290 - 1295 (2001)
The metal-catalyzed, and metal-catalyzed enantioselective, intermolecular additions of alkyl radicals to imines have been investigated. The reaction proceeds well for imines having both activating and deactivating nitrogen substituents, and can be controlled and accelerated to a high extent by the use of Lewis acids. For imines having different carbon substituents, it has been observed that those derived from glyoxylate react much faster than those derived from 3-oxopropionate or benzaldehyde. The intermolecular radical addition can be carried out for different types of imines with alkyl and alkoxyalkyl radicals and it is demonstrated that it is possible to perform the radical addition in a catalytic enantioselective fashion with moderate yield and enantioselectivity. On the basis of the experimental results and theoretical calculations the mechanism for the radical addition to imines is discussed.
Photoinduced Formation of β-Oxy-α,α-disubstituted-α-amino Acid Derivatives from Ketoximes
Torrente, Susana,Alonso, Ricardo
, p. 1985 - 1987 (2007/10/03)
(matrix presented) The first intermolecular radical addition onto ketoxime ethers is described. β-Oxygenated quaternary α-amino acid derivatives II were obtained upon irradiation of α-alkoxycarbonyl ketoxime ethers I in the presence of suitable α-alkoxy carbon radical precursors and a sensitizer.
α-Functionalized Amino Acid Derivatives. A Synthetic Approach of Possible Biogenetic Importance
Herscheid, Jacobus D. M.,Nivard, Rutger J. F.,Tijhuis, Marian W.,Scholten, Henk P. H.,Ottenheijm, Harry C. J.
, p. 1880 - 1885 (2007/10/02)
A new and efficient approach of general applicability to the synthesis of α-functionalized α-amino acid derivatives 3 is described.It is based upon the proposal that the biosynthesis of such compounds might occur via oxidation of an N-acylated amino acid
