732-21-8Relevant academic research and scientific papers
Mild and convenient one-pot synthesis of 1,3,4-oxadiazoles
Stabile, Paolo,Lamonica, Alessandro,Ribecai, Arianna,Castoldi, Damiano,Guercio, Giuseppe,Curcuruto, Ornella
supporting information; experimental part, p. 4801 - 4805 (2010/10/02)
A mild, general, convenient, and efficient one-pot synthesis of 2-phenyl-5-substituted-1,3,4-oxadiazoles is described. Both (hetero)aryl and alkyl carboxylic acids were efficiently condensed with benzohydrazide in the presence of TBTU to give diacylhydrazine intermediates. The latter underwent a smooth TsCl-mediated cyclodehydration reaction to afford 2-phenyl-5-substituted- 1,3,4-oxadiazoles in good to very good yields.
Hypervalent iodine oxidation of acid hydrazides: A new synthesis of N,N'-diacylhydrazines
Prakash, Om,Sharma, Vijay,Sadana, Anil
, p. 3371 - 3377 (2007/10/03)
Hypervalent iodine oxidation of p-substituted benzohydrazides (1a-h), phenylacetohydrazide (1i) and heterocyclic acid hydrazides (1j-l) using one equivalent of iodobenzene diacetate in dry dichloromethane or acetonitrile leads to dimerization thereby providing a new and facile method for the synthesis of N,N-diacylhydrazines 2.
