73215-92-6

Usage

Uses

Used in Medicinal Chemistry:
4a,5,5a,6,6a,6b,7,7a-Octahydro-7,7a-dihydroxy-3,6b-dimethyl-5-methylenecycloprop[2,3]indeno[5,6-b]furan-2(4H)-one is used as a building block for the synthesis of new pharmaceuticals or agrochemicals due to its unique structure and functional groups. Its potential biological activities make it a promising candidate for the development of novel therapeutic agents.
Used in Pharmaceutical Research and Development:
In the pharmaceutical industry, 4a,5,5a,6,6a,6b,7,7a-Octahydro-7,7a-dihydroxy-3,6b-dimethyl-5-methylenecycloprop[2,3]indeno[5,6-b]furan-2(4H)-one is used as a starting material for the synthesis of new compounds with potential therapeutic effects. Its structural features and functional groups can be leveraged to create innovative drugs with improved efficacy and safety profiles.
Used in Agrochemical Development:
4a,5,5a,6,6a,6b,7,7a-Octahydro-7,7a-dihydroxy-3,6b-dimethyl-5-methylenecycloprop[2,3]indeno[5,6-b]furan-2(4H)-one is also used in the agrochemical industry for the development of new pesticides or herbicides. Its unique structure and functional groups may contribute to the creation of more effective and environmentally friendly agrochemicals.

Upstream product

• 66395-03-7 chloranthalactone B 
• 66395-02-6 chloranthalactone A 

Relevant academic research and scientific papers

Chlojapolactone A, an unprecedented 1,3-dioxolane linked-lindenane sesquiterpenoid dimer from Chloranthus japonicus

Chlojapolactone A (1), a novel lindenane sesquiterpenoid dimer with an unprecedented 1,3-dioxolane linkage, was isolated from Chloranthus japonicus. Its structure and absolute configuration was elucidated by combined spectral, computational, and chemical approaches. Compound 1 exhibited potential inhibitory effects on nitric oxide production in RAW 264.7 cells.

Diverse Chemosensitizing 8,9-Secolindenane-Type Sesquiterpenoid Oligomers and Monomers from Sarcandra glabra

The theoretical analysis and biomimetic conversion confirmed that the oxidative cleavage of the Δ8,9 double bond of chloranthalactone A (I), an abundant lindenane-type sesquiterpenoid in Chloranthaceae plants, generates 8,9-secolindenane (II) with active aldehyde and maleic anhydride fragments that can capture other fragments and produce oligomeric molecules. A careful phytochemical investigation of the leaves of Sarcandra glabra led to the discovery of eight novel 8,9-secolindenane-type sesquiterpenoid oligomers (sarglalactones A-H, compounds 1-8), including three unprecedented trimers (1-3), five unusual dimers (4-8), and five 8,9-secolindenane monomers (sarglalactones I-M, 9-13). Their structures were determined by comprehensive HRMS, NMR, circular dichroism, and X-ray diffraction analyses. Bioassay results showed that these oligomers significantly reversed the multidrug resistance of MCF-7/doxorubicin (DOX) cells and increased the sensitivity of U2 OS cells to DOX by downregulating the HMGB1 expression.

Studies on the Constituents of Chloranthus ssp. III. Six Sesquiterpenes from Chloranthus japonicus

Six sesquiterpene lactones (I-VI) were isolated and characterized as constituents of Chlorantus japonicus (Chloranthraceae).The lactones chloranthalactone A-E (I-V) were found to be lindenane derivatives, and lactone VI was identified as atractylenolide II.The structure of chloranthalactone C (III) was determined by X-ray chrystallographic analysis of a crystal of III in conjunction with the negative Cotton effect in the optical rotatory dispersion (ORD) curve and negative circular dichroism curve of the ketoalcohol (XII) prepared from III.The stereostructures of chlorantholactone A and B (I and II) were deduced from the ORD curves of the degradation products (VII and X).The cytotoxixities of these lactones against mouse lymphosarcoma L-5178Y cells were determined in comparison with that of helenalin, and they were found to show moderate cytotoxic effects.Keywords- Chloranthus japonicus; sesquiterpene lactones; lindendane derivatived; X-ray chrystallographic analysis; structural elucidation; cytotoxicity; mouse lymphosarcoma l-5178Y cells