73221-19-9

Usage

Uses

Used in Drug Discovery and Development:
2-(trifluoromethyl)imidazo[1,2-a]pyridine-3-carboxylic acid is utilized as a key component in the development of pharmaceutical compounds. Its unique structure allows it to be a versatile building block in the synthesis of various drugs, potentially leading to the discovery of new therapeutic agents.
Used in Research and Development of New Materials:
2-(trifluoromethyl)imidazo[1,2-a]pyridine-3-carboxylic acid is also employed in the research and development of innovative materials. Its distinctive properties make it a promising candidate for the creation of novel substances with potential applications in various industries.
Used in Organic Chemistry Research:
2-(trifluoromethyl)imidazo[1,2-a]pyridine-3-carboxylic acid serves as an important tool in organic chemistry research. Its unique structure and properties facilitate the study of chemical reactions and mechanisms, contributing to a deeper understanding of organic chemistry principles.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 2-(trifluoromethyl)imidazo[1,2-a]pyridine-3-carboxylic acid is used to explore its potential in the development of new drugs and therapeutic agents. Its unique features make it a valuable asset in the search for novel treatments and pharmaceutical advancements.

InChI:InChI=1/C9H5F3N2O2/c10-9(11,12)7-6(8(15)16)14-4-2-1-3-5(14)13-7/h1-4H,(H,15,16)

Upstream product

• 87378-58-3 3-(t-butoxycarbonyl)-2-(trifluoromethyl)-imidazo<1,2-a>pyridine 
• 108438-46-6 3-(ethoxycarbonyl)-2-(trifluoromethyl)imidazo<1,2-a>pyridine 

Relevant academic research and scientific papers

Chalcone compound and applications thereof

The present invention relates to a chalcone-containing compound represented by a general formula (I), and a pharmaceutically acceptable salt, a solvate and a prodrug thereof, wherein the substituentsR1, R2, R3, R4, R5, R6, Q and n have the meanings given in the specification. The invention further relates to applications of the compound represented by the general formula (I) in preparation of anti-tumor drugs, and applications of the compound and the pharmaceutically acceptable salt, solvate and prodrug thereof in preparation of drugs for preventing and/or relieving cancers caused by tumor cells of human tissues or organs, wherein the cancers are preferably colon cancer, liver cancer, lymphoma, lung cancer, esophageal cancer, breast cancer, central nervous system tumor, melanoma, skin cancer, ovarian cancer, cervical cancer, kidney cancer, leukemia, prostate cancer, pancreatic cancer, bladder cancer, rectal cancer, osteosarcoma, nasopharyngeal cancer, gastric cancer and the like.

Potent, selective, orally bioavailable inhibitors of tumor necrosis factor-α converting enzyme (TACE): Discovery of indole, benzofuran, imidazopyridine and pyrazolopyridine P1′ substituents

Potent and selective inhibitors of tumor necrosis factor-α converting enzyme (TACE) were discovered with several new heterocyclic P1′ groups in conjunction with cyclic β-amino hydroxamic acid scaffolds. Among them, the pyrazolopyridine provided the best o

FLUOROCARBON DERIVATIVES OF NITROGEN. PART 11. SYNTHESIS OF SOME 2-(TRIFLUOROMETHYL)IMIDAZOPYRIDINES FROM TRIFLUOROACETONITRILE

3-(t-Butoxycarbonyl)-2-(trifluoromethyl)imidazopyridine, prepared from trifluoroacetonitrile and pyridinium t-butoxycarbonylmethylide, reacts smoothly with trifluoroacetic acid to provide 2-(trifluoromethyl)imidazopyridine-3-carboxylic acid, which gives 2-(trifluoromethyl)imidazopyridine when heated. 3-Cyano-2-(trifluoromethyl)imidazopyridine can be obtained via treatment of trifluoroacetonitrile with pyridinium cyanomethylide, which is sufficiently reactive to effect nucleophilic displacement of fluorine from pentafluoropyridine under mild conditions pyridinium cyano(tetrafluoro-4-pyridyl)methylide>.

Reaction of Pyridinium t-Butoxycarbonylmethylide with Trifluoroacetonitrile

Pyridinium t-butoxycarbonylmethylide (I), generated by treatment of N-(t-butoxycarbonymethyl)pyridinium perchlorate with sodium hydride in acetonitrile, reacts with trifluoroacetonitrile to give 3-(t-butoxycarbonyl)-2-(trifluoromethyl)-imidazopyridine (II), pyridinium 4,5-dihydro-4-oxo-2,6-bis(trifluoromethyl)pyrimidin-5-ylide (III), and N-pyridinium perchlorate (IV).Formation of the last two products, plus the fact that when treated with sodium hydride the perchlorate (IV) yields the imidazopyridine (II), provides powerful evidence in support of a stepwise mechanism for the 1,3-dipolar cycloaddition involved in formation of the imidazopyridine nucleus in (II).