732245-99-7

Basic information

• Product Name: 5-ISOCYANATO-2-METHYL-PYRIDINE
• Synonyms: 5-ISOCYANATO-2-METHYL-PYRIDINE;Pyridine, 5-isocyanato-2-methyl- (9CI);5-ISOCYANATO-2-METHYL-PYRIDINE 95%;5-Isocyanato-2-methylpyridine ,95%;Pyridine, 5-isocyanato-2-Methyl-
• CAS NO: 732245-99-7
• Molecular Formula: C₇H₆N₂O
• Molecular Weight: 134.14
• Product Categories: PYRIDINE
• Mol File: 732245-99-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 203.9ºC at 760 mmHg
• Flash Point: 77.1ºC
• Appearance: /
• Density: 1.09g/cm3
• Vapor Pressure: 0.27mmHg at 25°C
• Refractive Index: 1.55
• CAS DataBase Reference: 5-ISOCYANATO-2-METHYL-PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-ISOCYANATO-2-METHYL-PYRIDINE(732245-99-7)
• EPA Substance Registry System: 5-ISOCYANATO-2-METHYL-PYRIDINE(732245-99-7)

Safety Data

• Hazardous Substances Data: 732245-99-7(Hazardous Substances Data)

Usage

Chemical Properties

Yellow liquid

InChI:InChI=1/C7H6N2O/c1-6-2-3-7(4-8-6)9-5-10/h2-4H,1H3

Upstream product

• 64038-04-6 6-methyl-nicotinoyl azide 
• 917-61-3 sodium isocyanate 
• 111770-91-3 (6-methylpyridin-3-yl)trifluoromethanesulfonate 
• 3222-47-7 6-methylnicotinic acid 
• 51598-76-6 6-methyl-nicotinoyl chloride 

Downstream Products

• 1384553-88-1 C₁₄H₁₂F₃N₃O₂ 
• 873697-71-3 methyl 4-[(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}phenyl)methyl]piperazine-1-carboxylate 
• 873697-65-5 4-{4-fluoro-3-[3-(6-methyl-pyridin-3-yl)-ureido]-benzyl}-piperazine-1-carboxylic acid tert-butyl ester 
• 873697-60-0 C₂₃H₃₀FN₅O₃ 

Relevant articles and documents

C-3 NOVEL TRITERPENONE WITH C-28 REVERSE AMIDE DERIVATIVES AS HIV INHIBITORS

Formula (I) The invention relates to C-3 novel triterpenone with C-28 reverse amide derivatives, related compounds, and pharmaceutical compositions useful for the therapeutic treatment of viral diseases and particularly HIV mediated diseases.

(+)-(2R,5S)-4-[4-cyano-3-(trifluoromethyl)phenyl]-2,5-dimethyl-N-[6- (trifluoromethyl)pyridin-3-yl]piperazine-1-carboxamide (YM580) as an orally potent and peripherally selective nonsteroidal androgen receptor antagonist

A novel series of trans-N-aryl-2,5-dimethylpiperazine-1-carboxamide derivatives was synthesized and their androgen receptor (AR) antagonist activities and in vivo antiandrogenic effects were evaluated. Pharmacological assays indicated that compound 33 was a potent AR antagonist, and subsequent optical resolution provided (+)-(2R,5S)4-[4-cyano-3-(trifluoromethyl)phenyl]-2, 5-dimethyl-N-[6(triflouromethyl)pyridin-3-yl]piperazine-1-carboxamide (33a, YM580) which exhibited the most potent antiandrogenic activity. Unlike bicalutamide, compound 33a decreased the weight of rat ventral prostate in a dose-dependent manner (ED50 = 2.2 mg/kg/day), and induced the maximum antiandrogenic effect, comparable to that of surgical castration, without significantly affecting serum testosterone levels. Compound 33a is a promising clinical candidate for prostate cancer monotherapy.