732250-24-7Relevant academic research and scientific papers
Asymmetric alkylation of diarylmethane derivatives
Wilkinson, James A.,Rossington, Steven B.,Ducki, Sylvie,Leonard, John,Hussain, Nigel
, p. 1833 - 1844 (2006)
Deprotonation-alkylation of prochiral diarylmethane substrates using sec-BuLi and (-)-sparteine has been carried out in excellent yields and up to 94% ee. A variety of enantioselective alkylations, silylations and stannylations have been performed on four
ORGANIC COMPOUNDS
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Page/Page column 71, (2009/09/28)
The invention relates to 3,5-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,5-substituted piperidine compound, and/or a method of treatment comprising administering a 3,5-substituted piperidine compound, a method for the manufacture of a 3,5-substituted piperidine compound, and novel intermediates and partial steps for its synthesis. The preferred compounds (which can also be present as salts) have the formula I wherein R1, R2, T, R3 and R4 are as defined in the specification.
Asymmetric alkylation of diarylmethane derivatives. Improved results using methoxyethoxy substituent
Wilkinson, James A.,Rossington, Steven B.,Leonard, John,Hussain, Nigel
, p. 5481 - 5483 (2007/10/03)
Alkylation of 2-methoxyethoxyphenyl phenyl methane using sec-BuLi and (-)-sparteine has been carried out in excellent yields and up to 94% ee. The best results were obtained in allylation reactions but methylation, ethylation, benzylation and trimethylsilylation have all been carried out with acceptable ee.
