732308-52-0

Upstream product

• 247191-05-5 (2S,3S,4S,5R)-1-methylene-2,3-O-isopropylidene-2,3-dihydroxy-4,5-epoxycyclopentane 
• 732308-48-4 (3aR,6S,6aS)-6-methoxy-2,2-dimethyldihydrofuro[3,4-d][1,3]dioxol-4(3aH)-one 
• 247191-04-4 (2R,3R,4S,5R)-2,3-O-isopropylidene-2,3-dihydroxy-4,5-epoxycyclopentanone 
• 115509-13-2 (3aR,6aR)-2,2-Dimethyl-3a,6a-dihydro-cyclopenta[1,3]dioxol-4-one 
• 63029-07-2 methyl 2,3-O-isopropylidene-α-D-lyxofuranoside 
• 4099-88-1 (3aS,6R,6aS)-6-(hydroxymethyl)-2,2-dimethyl-tetrahydrofuro[3,4-d]-[1,3]dioxol-4-ol 
• 732308-51-9 (1R,2S,3R,4S)-1-(N-benzyl)-(N-tert-butoxycarbonyl)amino-3,4-O-isopropylidene-5-methylenecyclopentane-2,3,4-triol 

Relevant academic research and scientific papers

Structure-activity relationships in aminocyclopentitol glycosidase inhibitors

Aminocyclopentitol analogs of β-D-glucose, β-D-galactose and α-D-galactose bearing alkyl substituents as aglycon mimics on the amine function were prepared and tested for inhibition of various glycosidases. N-benzyl-β-D-gluco derivatives 1-4 and N-benzyl-β-D-galacto derivative 5 inhibited β-galactosidase and β-glucosidase. N-benzyl-α-D- galacto aminocyclopentitol 6 strongly inhibited α-galactosidase. The inhibitory activities observed were generally stronger compared to those of their primary amine analogs. A structure-activity relationship analysis was carried out including data from thirty-five different aminocyclopentitol glycosidase inhibitors. The strongest inhibitions reported for any enzyme were associated with a perfect stereochemical match between aminocyclopentitol and glycosidase, including the α- or β-configuration of the amino-group corresponding to the enzyme's anomeric selectivity.