73234-91-0

Usage

Synonyms

2-(2-propynyl)-1,3-dimethylbenzene
2-(2-propyn-1-yl)-1,3-dimethylbenzene

Physical state

Colorless to light yellow liquid

Odor

Strong, sweet

Uses

Intermediate in the production of pharmaceuticals
Intermediate in the production of agrochemicals
Intermediate in the production of other organic compounds
Solvent in various industrial applications

Safety

Flammable and potentially hazardous material

Precautions

Appropriate safety measures should be taken when handling and storing the compound

Upstream product

• 1254784-75-2 C₁₁H₁₂O 
• 106-96-7 propargyl bromide 
• 21450-64-6 (2,6-dimethylphenyl)magnesium bromide 

Relevant academic research and scientific papers

Synthesis of allenes via Nickel-catalyzed cross-coupling reaction of propargylic bromides with grignard reagents

We describe a convenient method for the synthesis of terminal allenes from cross-coupling of propargylic bromide with Grignard reagent. The reaction of propargylic bromide with 1.2 equivalents of Grignard reagent mediated by Ni(acac)2 (2 mol%) and Ph3P (4 mol%) in THF may produce terminal allenes in good yields and high regioselectivities at room temperature. Georg Thieme Verlag Stuttgart · New York.

Preparation of thiolate-bridged dinuclear ruthenium complexes bearing a phosphine ligand and application to propargylic reduction of propargylic alcohols with 2-propanol

Novel thiolate-bridged dinuclear ruthenium complexes bearing a phosphine ligand, [CpRu{PhP(C6H4-o-S)2}RuCp](OTf) 2, [CpRu{PhP(C6H4-o-S)2}RuCp(OH 2)](OTf)2, and [CpFe{PhP(C6H 4-o-S)2}RuCp](OTf)2, are prepared and characterized by X-ray analysis. These dinuclear complexes work as effective catalysts toward propargylic reduction of propargylic alcohols with 2-propanol via allenylidene complexes as key intermediates to give the corresponding alkynes in good to high yields.

Conversion of alkyl- and arylallenes into 1-alkynes through metallated intermediates

A number of acetylenes RCH2C≡CH have been obtained by metallation of the allenes RCH=C=CH2 or mixtures of acetylenes and allenes with n-BuLi in THF-hexane and hydrolysis after allowing the metallated allenes to rearrange at roam temperature or by heating under reflux.