73239-22-2Relevant articles and documents
Amidoalkylating properties of 1-(N -acylamino)alkyltriphenylphosphonium salts
Pazdzierniok-Holewa, Agnieszka,Adamek, Jakub,Mazurkiewicz, Roman,Zielinska, Katarzyna
, p. 205 - 212 (2013/07/05)
Easily accessible 1-(N-acylamino)alkyltriphenylphosphonium salts react smoothly with nitrogen, sulfur, phosphorus and oxygen nucleophiles in the presence of (i-Pr)2EtN to give the expected α-amidoalkylation products, usually in good or very good yields. α-Amidoalkylation of dialkyl malonates or acetylacetates requires the application of a much stronger base (DBU) and gives the best results under the influence of microwave irradiation. α-Amidoalkylation of enamines was carried out successfully in the presence of (i-Pr)2EtN in a microwave reactor. 1-(N-Acylamino)alkyltriphenylphosphonium salts can be considered as new, convenient and effective α-amidoalkylation agents.