73240-32-1

Usage

Molecular Structure

Complex structure consisting of a sugar moiety with 6-deoxy and 2,3-O-(1-methylethylidene) substitutions, connected to a 1,2,4-triazine-3,5(2H,4H)-dione ring system.

Sugar Moiety

Contains a hexopyranosyl unit modified with a 6-deoxy substitution, and an O-(1-methylethylidene) group attached to positions 2 and 3.

1,2,4-Triazine-3,5(2H,4H)-dione Ring System

Consists of a triazine-dione ring system, potentially imparting unique chemical properties.

Biological Activity

The presence of the sugar moiety suggests potential biological activity, possibly as a carbohydrate-based pharmaceutical.

Chemical Properties

The triazine-dione ring system may confer unique chemical properties, making it valuable for organic synthesis or drug development.

Potential Applications

Further research is needed to fully understand the potential applications of 2-[6-deoxy-2,3-O-(1-methylethylidene)hexopyranosyl-4-ulose]-1,2,4-triazine-3,5(2H,4H)-dione, particularly in pharmaceuticals or organic synthesis.

Upstream product

• 114988-07-7 6-aza-1-(2',3',4'-O-acetyl-α-L-rhamnosyl)-uracil 
• 114988-08-8 6-aza-1-(α-L-rhamnosyl)-uracil 
• 7404-35-5 1,2,3,4-tetra-O-acetyl-L-rhamnopyranose 
• 114988-09-9 6-aza-1-(2',3'-O-isopropylidene-α-L-rhamnosyl)-uracil 

Relevant academic research and scientific papers

Relationship between the structure and cytotoxic activity of new unsaturated ketonucleosides tested on eight cell lines.

The synthesis and cytotoxic activity of 14 ketonucleosides on 8 normal, transformed and leukemic cell lines are described.Compounds 1, 2, 3, 4, 5, and 6 proved to be the most cytotoxic for transformed and leukemic cells; compound 7 presents an intermediate activity, whereas compounds 8, 9, 10, 11, 12, 13 and 14 exhibited little or no cytotoxicity. the presence of the or system in the sugar moiety of the molecule was required for cytotoxic activity.Introduction of bromine into the sugar moiety of compounds 1 made it highly toxic, whereas the introduction of an O-acetyl group into the sugar moiety of compound 5 seemed to moderate its cytotoxic activity.The degree of this activity was independent of the anomeric configuration, axial or equatorial position of the bases and the L or D configuration of the sugar.Ketonucleosides 1, 2, 3 and 5 inhibited DNA synthesis in leukemic REH6 cells more markedly than RNA and protein syntheses. ketonucleosides / unsaturated ketonucleosides / cytotoxicity / macromolecular synthesis / structure-activity relationship