73250-05-2Relevant academic research and scientific papers
Reactivity of silylated compounds with active methylene under microwave irradiation in heterogeneous dry media; application to the alkali metal fluoride-mediated silyl-Reformatsky reaction
Latouche, R.,Texier-Boullet, F.,Hamelin, J.
, p. 535 - 546 (2007/10/02)
The condensation of trimethylsilylacetic compounds 2a, 2b, (nitrile, ester) and trimethylsilylmethylphosphonic esters 2c with aromatic aldehydes 1, in the presence of alkali metal fluorides (potassium, cesium) unsupported or supported on alumina, magnesium oxide or clay (montmorillonite K10), is achieved by solvent-free techniques in a domestic microwave oven.The factors governing the reaction selectivity are studied.The silyl-Reformatsky reaction takes place in the presence of dried fluoride and leads to the silylated compound 3, which can be subsequently hydrolyzed to 4.The latter can be dehydrated to give the alkene 5.Keywords - alkali metal fluoride / silyl-Reformatsky reaction / nucleophilic activation / inorganic solid supports / trimethylsilyl-acetic compounds / microwave irradiation
