73274-92-7Relevant academic research and scientific papers
A Convenient Total Synthesis of (+/-)-Isoochracinic Acid, a Phthalide from Alternaria kikuchiana
Yeola, Suresh N.,Mali, R. S.
, p. 804 - 806 (2007/10/02)
Total synthesis of (+/-)-isoochracinic acid (7), starting from 2-formyl-6-methoxybenzoic acid (3) as the key intermediate is described.Compound (3) is obtained by heteroatom directed lithiation reaction on 2-methoxy-N-methylbenzamide (1).
Regiocontrolled Synthesis of Hydroxyphthalides. Synthesis of (+/-)-Isoochracinic Acid and a Zealeranone Intermediate
Trost, Barry M.,Rivers, Gordon T.,Gold, Jeffrey M.
, p. 1835 - 1838 (2007/10/02)
Metalation of 3-methoxy- and 3,5-dimethoxybenzyl alcohol followed by quenching with CO2 provided the phthalides.Bromination and solvolysis generated 7-methoxy- and 5,7-dimethoxyphthalaldehydic acid in a fully regiocontrolled reaction.The former served as
