73279-23-9

Upstream product

• 541-41-3 chloroformic acid ethyl ester 
• 73278-22-5 1-methyl-N⁶-<3-<3-<(dimethylamino)methyl>phenoxy>propyl>-1H-1,2,4-triazole-3,5-diamine 

Downstream Products

• 73278-74-7 N⁵-{3-[3-(dimethylamino-methyl)-phenoxy]-propyl}-1,N³-dimethyl-1H-[1,2,4]triazole-3,5-diamine 

Relevant academic research and scientific papers

1,2,4-TRIAZOLE-3,5-DIAMINE DERIVATIVES

The invention relates to compounds of the formula (I) STR1 and physiologically acceptable salts, hydrates and bioprecursors thereof, in whichR 1 and R 2 represent hydrogen, an aliphatic or cycloaliphatic group, or R 1 and R 2 together with the nitrogen atom form a 5 to 10 membered heterocyclic ring:Alk represents a straight or branched alkylene chain;Q represents furan, thiophen or benzene ring which is incorporated into the rest of the molecule; X represents--CH 2--, STR2--O--or--S--where R 6 represents hydrogen or methyl;n represents zero, 1 or 2; m represents 2, 3 or 4;R 3 represents hydrogen, a substituted or unsubstituted aliphatic or aryl group and;R 4 and R 5, which may be the same or different, each represent hydrogen, a substituted or unsubstituted aliphatic, aryl, or together with the nitrogen atom form a heterocyclic group.

TRIAZOLE ACYLAMINES, PHARMACEUTICAL COMPOSITIONS THEREOF AND METHOD OF USE THEREOF

The invention relates to compounds of the general formula (I) STR1 and physiologically acceptable salts, hydrates and bioprecursors thereof, in whichR 1 and R 2, which may be the same of different, each represent hydrogen, C 1 alkyl, cycloalkyl, alkenyl, alkynyl, aralkyl, trifluoroalkyl, or alkyl substituted by hydroxy, alkoxy, amino alkylamino dialkylamino or cycloalkyl or R 1 and R 2 may together with the nitrogen atom to which they are attached form a 5 to 10 membered ring which may be saturated or may contain at least one double bond, may be unsubstituted or may be substituted by one or more C 1-3 alkyl groups or a hydroxy group and/or may contain another heteroatom which is oxygen or sulphur; Alk represents a straight or branched alkylene chain of 1 to 6 carbon atoms,Q represents a furan or thiophene ring in which incorporation into the rest of the molecule is through bonds at the 2-and 5-positions, the furan ring optionally bearing a further substituent R 6 adjacent to the group R 1 R 2 N-Alk, or Q represents a benzene ring in which incorporation into the rest of the molecule is through bonds at the 1-and 3-or 1-and 4-positions; R 6 represents halogen or C 1-4 alkyl which may be substituted by hydroxy or C 1-4 alkoxy;x represents--CH 2--,--O--,--S--or STR2 where R 5 represents hydrogen or methyl; n represents zero, 1 or 2;m represents 2, 3 or 4;R 3 represents hydrogen, alkyl, alkenyl, aralkyl, hydroxyalkyl with at least two carbon atoms, alkoxyalkyl, or aryl, andR 4 represents hydrogen, alkyl, alkenyl or aralkyl and R 7 represents the group COR 8 where R 8 represents hydrogen, alkyl, aryl, aralkyl, alkoxy, heteroaryl or monocyclic heteroarylalkyl or R 7 represents the group SO 2 R 9 where R 9 represents alkyl or aryl, or R. sub.7 represents the group STR3 where Y is oxygen or sulphur and R. sub.10 represents hydrogen, alkyl, cycloalkyl, aryl or aralkyl. The compounds of formula (I) show pharmacological activity as selective histamine H 2-antagonists.