73285-56-0

Basic information

• Product Name: 2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen-7-yl D-glucopyranosiduronic acid
• CAS NO: 73285-56-0
• Molecular Formula: C₂₁H₁₈O₁₂
• Molecular Weight: 462.3604
• Mol File: 73285-56-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 892.5°C at 760 mmHg
• Flash Point: 315.2°C
• Density: 1.81g/cm³
• Vapor Pressure: 3.25E-34mmHg at 25°C
• Refractive Index: 1.763
• CAS DataBase Reference: 2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen-7-yl D-glucopyranosiduronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen-7-yl D-glucopyranosiduronic acid(73285-56-0)
• EPA Substance Registry System: 2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen-7-yl D-glucopyranosiduronic acid(73285-56-0)

Safety Data

• Hazardous Substances Data: 73285-56-0(Hazardous Substances Data)

Upstream product

• 491-70-3 2-(3,4-Dihydroxy-phenyl)-5,7-dihydroxy-chromen-4-on 
• 1245697-26-0 UDP-glucuronic acid 

Relevant articles and documents

Identification of flavone glucuronide isomers by metal complexation and tandem mass spectrometry: Regioselectivity of uridine 5′-diphosphate- glucuronosyltransferase isozymes in the biotransformation of flavones

Flavone glucuronide isomers of five flavones (chrysin, apigenin, luteolin, baicalein, and scutellarein) were differentiated by collision-induced dissociation of [Co(II) (flavone-H) (4,7-diphenyl-1,10-phenanthroline) 2]+ complexes. The complexes were generated via postcolumn addition of a metal-ligand solution after separation of the glucuronide products generated upon incubation of each flavone with an array of uridine 5′-diphosphate (UDP)-glucuronosyltransferase (UGT) isozymes. Elucidation of the glucuronide isomers allowed a systematic investigation of the regioselectivity of 12 human UGT isozymes, including 8 UGT1A and 4 UGT2B isozymes. Glucuronidation of the 7-OH position was the preferred site for all the flavones except for luteolin, which possessed adjacent hydroxyl groups on the B ring. For all flavones and UGT isozymes, glucuronidation of the 5-OH position was never observed. As confirmed by the metal complexation/MS/MS strategy, glucuronidation of the 6-OH position only occurred for baicalein and scutellarein when incubated with three of the UGT isozymes.