73289-84-6Relevant academic research and scientific papers
Enantioselective nitrogen transfer to sulfides from nitridomanganese(V) complexes
Tomooka, Craig S.,Carreira, Erick M.
, p. 3773 - 3784 (2002)
We describe the facile preparation of novel, optically active nitridomanganese (V) complexes which serve as reagents for the electrophilic amination of sulfides. This amination method has several appealing features, including: i) the facile preparation of large quantities of the starting nitridomanganese reagent 3, ii) the preparation of acylsulfilimines 2 in optically active form, and iii) the mild reaction conditions employed.
Phosphination of Phenol Derivatives and Applications to Divergent Synthesis of Phosphine Ligands
Li, Chenchen,Zhang, Kezhuo,Zhang, Minghao,Zhang, Wu,Zhao, Wanxiang
supporting information, p. 8766 - 8771 (2021/11/20)
We describe a general and efficient protocol for the synthesis of organophosphine compounds from phenols and phosphines (R2PH) via a metal-free C-O bond cleavage and C-P bond formation process. This approach exhibits broad substrate scope and excellent functional group tolerance. The synthetic utilities of this protocol were demonstrated by the synthesis of chiral ligands via the various transformations of cyano groups and their applications in asymmetric catalysis.
Facile one-pot transformation of phenols into o-cyanophenols
Nakai, Yuhta,Moriyama, Katsuhiko,Togo, Hideo
, p. 6077 - 6083 (2015/03/30)
The treatment of phenols with paraformaldehyde in the presence of MgCl2 and Et3N in THF at 80 C, followed by reaction with molecular iodine and aq. ammonia at room temperature provided the corresponding o-cyanophenols in moderate to good yields. The present reaction is a one-pot transformation of phenols into o-cyanophenols using much less expensive reagents than are typically used; the reaction is free of both transition-metals and cyanide. The utility of this reaction was highlighted during our preparation of Febuxostat from p-bromophenol.
