733000-63-0

Upstream product

• 733000-64-1 (S)-2-[(R)-2-Benzyloxy-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-methyl-hex-4-enoic acid methoxy-methyl-amide 
• 733000-61-8 (S)-2-((R)-2-Benzyloxy-1-hydroxy-ethyl)-5-methyl-hex-4-enoic acid methoxy-methyl-amide 
• 733000-60-7 (S)-2-((R)-2-Benzyloxy-1-hydroxy-ethyl)-5-methyl-hex-4-enoic acid ethyl ester 
• 870-63-3 prenyl bromide 
• 106058-91-7 (+)-(R)-ethyl 4-benzyloxy-3-hydroxybutanoate 
• 3314-49-6 octyllithium 
• 733000-65-2 (S)-5-[(R)-2-Benzyloxy-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2-methyl-tetradec-2-en-6-one 

Downstream Products

• 733000-66-3 (2R,3R,4S)-1-Benzyloxy-3-(3-methyl-but-2-enyl)-dodecane-2,4-diol 

Relevant academic research and scientific papers

Synthesis of modified Weinreb amides: N-tert-butoxy-N-methylamides as effective acylating agents

An efficient preparation of N-methyl-O-tert-butylhydroxylamine hydrochloride has been settled, which allowed the synthesis of modified Weinreb amides. Nucleophilic addition of organolithium and Grignard reagents on these N-tert-butoxy-N-methylamides afforded efficiently the corresponding ketones and reduction with DIBAL furnished the corresponding aldehydes in good yields up to 97%.

An efficient ruthenium-catalyzed formal synthesis of (-)-isoavenaciolide

A formal synthesis of (-)-isoavenaciolide (1) by two different routes is reported. The first approach, leading to a key precursor 2 of (-)-isoavenaciolide (1), features the stereoselective construction of the three contiguous stereogenic centers by Evans