733035-43-3

Basic information

• Product Name: 1H-Indole-6-carboxylic acid, 7-methoxy-, methyl ester
• Synonyms: 7-Methoxy-1H-indole-6-carboxylic acid methyl ester
• CAS NO: 733035-43-3
• Molecular Formula: C11H11NO3
• Molecular Weight: 205.21000
• Mol File: 733035-43-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1H-Indole-6-carboxylic acid, 7-methoxy-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-6-carboxylic acid, 7-methoxy-, methyl ester(733035-43-3)
• EPA Substance Registry System: 1H-Indole-6-carboxylic acid, 7-methoxy-, methyl ester(733035-43-3)

Safety Data

• Hazardous Substances Data: 733035-43-3(Hazardous Substances Data)

Usage

Structure

A heterocyclic compound with a methyl ester group

Functional groups

Methoxy (-OCH3) at the 7-position, carboxyl (-COOH) at the 6-position, and indole ring system

Pharmaceutical and industrial applications

Potential uses in pharmaceutical research and drug development

Biological activity

The presence of the 7-methoxy group can potentially influence biological activity

Pharmacokinetic properties

The presence of the 7-methoxy group can potentially influence pharmacokinetic properties

Unique structure

The compound has a unique structure due to the combination of the indole ring system and the methoxy and carboxyl groups.

Upstream product

• 1400093-68-6 (E)-methyl 4-(2-(dimethylamino)vinyl)-2-methoxy-5-methyl-3-nitrobenzoate 
• 1245529-30-9 methyl 2-methoxy-4,5-dimethyl-3-nitrobenzoate 
• 1245534-33-1 methyl 2-methoxy-4,5-dimethylbenzoate 
• 50-85-1 2-hydroxy-p-toluic acid 
• 733035-42-2 C₁₁H₁₀BrNO₃ 
• 81245-24-1 methyl 4-methyl-2-methoxybenzoate 
• 39503-58-7 methyl 5-bromo-2-methoxy-4-methylbenzoate 
• 733035-40-0 5-bromo-2-methoxy-4-methyl-3-nitro-benzoic acid methyl ester 

Downstream Products

• 1400093-70-0 7-methoxy-1H-indole-6-carbonyl chloride 
• 1400093-71-1 2-(4-(pyrrolidin-1-yl)phenyl)pyrano[3,2-g]indol-4(9H)-one 

Relevant articles and documents

Optimization of a small tropomyosin-related kinase B (TrkB) agonist 7,8-dihydroxyflavone active in mouse models of depression

Structure-activity relationship study shows that the catechol group in 7,8-dihdyroxyflavone, a selective small TrkB receptor agonist, is critical for agonistic activity. To improve the poor pharmacokinetic profiles intrinsic to catechol-containing molecules and to elevate the agonistic effect of the lead compound, we initiated the lead optimization campaign by synthesizing various bioisosteric derivatives. Here we show that the optimized 2-methyl-8-(4′- (pyrrolidin-1-yl)phenyl)chromeno[7,8-d]imidazol-6(1H)-one derivative possesses enhanced TrkB stimulatory activity. Chronic oral administration of this compound significantly reduces the immobility in forced swim test and tail suspension test, two classical antidepressant behavioral animal models, which is accompanied by robust TrkB activation in hippocampus of mouse brain. Further, in vitro ADMET studies demonstrate that this compound possesses the improved features compared to the previous lead compound. Hence, this optimized compound may act as a promising lead candidate for in-depth drug development for treating various neurological disorders including depression.

VIRAL POLYMERASE INHIBITORS

An isomer, enantiomer, diastereoisomer or tautomer of a compound, represented by formula (I): wherein wherein A, B, R2, R3, L, M1, M2, M3, M4, Y1, Y0, Z and Sp are as defined in claim 1, or a salt thereof, as an inhibitor of HCV NS5B polymerase.