733038-80-7Relevant academic research and scientific papers
Method for synthesizing palbociclib
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, (2018/03/24)
The invention discloses a method for synthesizing palbociclib. The method comprises the following steps: (1) carrying out substitution reaction between a compound of a formula VI and a compound of a formula VII, so as to obtain a compound of a formula VIII; (2) carrying out acylation reaction between the compound of the formula VIII and a compound of a formula III, so as to obtain a compound of aformula IX; (3) carrying out self-coupling on the compound of the formula IX in the presence of a metal catalyst, so as to obtain a compound of a formula X; and (4) carrying out deprotection on the compound of the formula X, so as to obtain a compound of a formula XI, namely the palbociclib. Compared with the prior art, the method has the advantages that a noble metal catalyst or a toxic dehydrogenation reagent or the like is not used, the reaction conditions are mild, the reaction selectivity is good, the total yield is relatively high, the total yield is relatively high, the liquid-phase purity of the product is high, the production cost is substantially lowered, and the method is relatively suitable for industrial production.
2-AMINOPYRIDINE SUBSTITUTED HETEROCYCLES AS INHIBITORS OF CELLULAR PROLIFERATION
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Page 31-32, (2008/06/13)
The present invention provides substituted 2-aminopyridines of formula (I), wherein R1, A1, W, X, and Y are as defined in the specification, useful in treating cell proliferative disorders. The novel compounds of the present invention are potent inhibitors of cyclin-dependent kinases 4 (Cdk4).
