73304-48-0Relevant academic research and scientific papers
IMINIUM SALT ORGANOCATALYSTS, METHODS OF MAKING, AND METHODS OF USING
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Page/Page column 30-32; 35-36, (2018/04/11)
Aspects of the present disclosure include compositions comprising iminium catalyst, methods of making, methods of using, and the like.
An Iminium Salt Organocatalyst for Selective Aliphatic C-H Hydroxylation
Wang, Daoyong,Shuler, William G.,Pierce, Conor J.,Hilinski, Michael K.
supporting information, p. 3826 - 3829 (2016/08/16)
The first examples of catalysis of aliphatic C-H hydroxylation by an iminium salt are presented. The method allows the selective organocatalytic hydroxylation of unactivated 3° C-H bonds at room temperature using hydrogen peroxide as the terminal oxidant. Hydroxylation of an unactivated 2° C-H bond is also demonstrated. Furthermore, improved functional group compatibility over other catalytic methods is reported in the form of selectivity for aliphatic C-H hydroxylation over alcohol oxidation. On the basis of initial mechanistic studies, an oxaziridinium species is proposed as the active oxidant.
