733049-48-4

Basic information

• Product Name: C₃₄H₃₉N₅O₇
• Synonyms: C₃₄H₃₉N₅O₇
• CAS NO: 733049-48-4
• Molecular Weight: 629.713
• Mol File: 733049-48-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₄H₃₉N₅O₇(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₄H₃₉N₅O₇(733049-48-4)
• EPA Substance Registry System: C₃₄H₃₉N₅O₇(733049-48-4)

Safety Data

• Hazardous Substances Data: 733049-48-4(Hazardous Substances Data)

Upstream product

• 733049-39-3 [1-(4-nitro-benzyl)-2-oxo-piperidin-3-yl]-carbamic acid tert-butyl ester 
• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 99780-98-0 (+/-)-3-<(tert-butoxycarbonyl)amino>-2-piperidone 
• 207857-19-0 N,N'-bis(benzyloxycarbonyl)-N''-trifluoromethane-sulfonylguanidine 
• 733049-46-2 [1-(4-amino-benzyl)-2-oxo-piperidin-3-yl]-carbamic acid tert-butyl ester 

Downstream Products

• 804554-74-3 [1-(4-guanidino-benzyl)-2-oxo-piperidin-3-yl]-carbamic acid tert-butyl ester 

Relevant articles and documents

Design, synthesis and biological activity of a targeted library of potential tryptase inhibitors

We have designed, synthesized, and tested two small collections of potential tryptase inhibitors. The first library consists of diversely N-substituted 3-aminopiperidin-2-ones 6, and the second (compounds 7) was prepared by dimerising compounds 6 through the 3-amino function using diverse carbon chains. We have established efficient routes for obtaining 6 both in solution and on solid supports. We have also compared the dimerisation on-resin and in solution. Four of the compounds showed a high degree of tryptase inhibition at 1 μM, but none surpassed the tryptase inhibition activity of BABIM.