73305-12-1 Usage
Uses
Used in Pharmaceutical Industry:
4-(2-NITROPHENYL)-3-THIOSEMICARBAZIDE is used as a chemical intermediate for the synthesis of pharmaceutical compounds. Its unique functional groups contribute to the development of new drugs with potential therapeutic applications.
Used in Agricultural Industry:
In the agricultural sector, 4-(2-NITROPHENYL)-3-THIOSEMICARBAZIDE is employed as a precursor in the production of agrochemicals. Its chemical properties allow for the creation of compounds that can be used in pest control and crop protection.
Used in Analytical Chemistry:
4-(2-NITROPHENYL)-3-THIOSEMICARBAZIDE is utilized as a reagent or analytical tool in various chemical analyses. Its distinct properties make it suitable for detecting or quantifying specific substances in complex samples.
Safety and Handling:
Due to the potential hazards associated with 4-(2-NITROPHENYL)-3-THIOSEMICARBAZIDE, it is essential to follow proper safety protocols during its handling, use, and disposal. This includes wearing appropriate personal protective equipment, working in well-ventilated areas, and adhering to waste disposal regulations to minimize environmental and health risks.
Check Digit Verification of cas no
The CAS Registry Mumber 73305-12-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,3,3,0 and 5 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 73305-12:
(7*7)+(6*3)+(5*3)+(4*0)+(3*5)+(2*1)+(1*2)=101
101 % 10 = 1
So 73305-12-1 is a valid CAS Registry Number.
InChI:InChI=1/C7H8N4O2S/c8-10-7(14)9-5-3-1-2-4-6(5)11(12)13/h1-4H,8H2,(H2,9,10,14)
73305-12-1Relevant academic research and scientific papers
Thio- and selenosemicarbazones as antiprotozoal agents against Trypanosoma cruzi and Trichomonas vaginalis
álvarez-Márquez, Manuel,Escario, José Antonio,Espinosa-Buitrago, Teresa,Fernández-Bola?os, José G.,Fonseca-Berzal, Cristina,Gómez-Barrio, Alicia,Gómez-Nú?ez, María,Ibá?ez-Escribano, Alexandra,López, óscar,Lacueva-Arnedo, Manuel,Martín-Pérez, Tania,Martínez-Montiel, Mónica,Merino-Montiel, Penélope,Montiel-Smith, Sara
, p. 781 - 791 (2022/03/09)
Herein, we report the preparation of a panel of Schiff bases analogues as antiprotozoal agents by modification of the stereoelectronic effects of the substituents on N-1 and N-4 and the nature of the chalcogen atom (S, Se). These compounds were evaluated towards Trypanosoma cruzi and Trichomonas vaginalis. Thiosemicarbazide 31 showed the best trypanocidal profile (epimastigotes), similar to benznidazole (BZ): IC50 (31)=28.72 μM (CL-B5 strain) and 33.65 μM (Y strain), IC50 (BZ)=25.31 μM (CL-B5) and 22.73 μM (Y); it lacked toxicity over mammalian cells (CC50 > 256 μM). Thiosemicarbazones 49, 51 and 63 showed remarkable trichomonacidal effects (IC50?=16.39, 14.84 and 14.89 μM) and no unspecific cytotoxicity towards Vero cells (CC50 ≥ 275 μM). Selenoisosters 74 and 75 presented a slightly enhanced activity (IC50=11.10 and 11.02 μM, respectively). Hydrogenosome membrane potential and structural changes were analysed to get more insight into the trichomonacidal mechanism.
