73316-19-5

Upstream product

• 73316-21-9 3-(4-phenoxyphenoxy)propanonitrile 
• 831-82-3 4-Phenoxyphenol 
• 73316-22-0 3-(4-phenoxyphenoxy)propanoic acid 

Downstream Products

• 73316-15-1 C₁₇H₁₄N₂O₄ 
• 146745-97-3 6-phenoxy-2H-benzo[b]pyran 

Relevant academic research and scientific papers

An efficient synthesis of 4-chromanones

A two step efficient and practical synthesis of a variety of 4-chromanones is described. Phenols undergo a Michael addition to acrylonitriles in the presence of catalytic amounts of potassium carbonate and tert-butanol to generate the corresponding 3-aryloxypropanenitriles in 50-93% yields. Treatment of the resulting aryloxypropionitriles with 1.5 equiv of TfOH and 5 equiv of TFA, followed by an aqueous work up afforded 4-chromanones in moderate to excellent yields.

Some Phenoxy-2H-benzo[b]pyrans

Successful methods have been developed for the syntheses of 6-, 7- and 8-phenoxy-2H-benzo-[b]pyrans, 4-,5-,6-,7- and 8-phenoxy-2,2-dimethyl-2H-benzo[b]pyrans and 4- and 7-phenoxy-2,2-diphenyl-2H-benzo[b]pyrans.

Phenyl or phenoxy substituted spiro-imidazolidinedione derivatives

Novel phenyl or phenoxy substituted spiro-imidazolidinedione derivatives useful as aldose reductase inhibitors and as therapeutic agents for the treatment of chronic diabetic complications are disclosed. The derivatives include the phenyl or phenoxy subst