73323-67-8

Basic information

• Product Name: N-acetyl-α-aminopropionaldehyde
• Synonyms: N-acetyl-α-aminopropionaldehyde
• CAS NO: 73323-67-8
• Molecular Weight: 115.132
• Mol File: 73323-67-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-acetyl-α-aminopropionaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: N-acetyl-α-aminopropionaldehyde(73323-67-8)
• EPA Substance Registry System: N-acetyl-α-aminopropionaldehyde(73323-67-8)

Safety Data

• Hazardous Substances Data: 73323-67-8(Hazardous Substances Data)

Upstream product

• 5202-78-8 acetylaminoethylene 
• 201230-82-2 carbon monoxide 

Downstream Products

• 97-69-8 (S)-acetamidoalanine 
• 19436-52-3 (R)-2-(acetylamino)propanoic acid 
• 708-74-7 2,4-diamino-6-methylpteridine 
• 708-75-8 2-amino-6-methylpteridin-4(1H)-one 

Relevant articles and documents

Asymmetric Hydroformylation and Hydrocarboxylation of Enamides. Synthesis of Alanine and Proline

Carbonyltris(triphenylphosphine)hydridorhodium (1) catalyzed the hydroformylation of N-vinylimides in the presence of optically active 2,3-O-isopropylidene-2,3-dihydroxy-1,4-bis(diphenylphosphino)butane (DIOP) or 2,3-O-isopropylidene-2,3-dihydroxy-1,4-bis(5H-dibenzophospholyl)butane (DIPHOL) to afford optically active α-amido aldehydes.Linear disubstituted N-vinylimides or -amides reacted very sluggishly, while the cyclic N-acyl-2-pyrroline (19) was very reactive.In the unsubstituted N-vinylimides moderate (20-40percent ee) asymmetric induction was observed.The optically active α-amido aldehydes were readily converted to the corresponding α-amino acids.Asymmetric hydrocarboxylation of the same substrates in the presence of bis(triphenylphosphine)palladium chloride (2) produced α-amido esters in low optical purity.