7333-52-0

Basic information

• Product Name: CYCLOPENTYLTRIPHENYLPHOSPHONIUM BROMIDE
• Synonyms: cyclopentyl(triphenyl)phosphanium,bromide;CYCLOPENTYLTRIPHENYLPHOSPHONIUM BROMIDE;Cyclopentyltriphenylphosphonium bromide 97%;Cyclopentyltriphenylphosphonium bromide, 98+%
• CAS NO: 7333-52-0
• Molecular Formula: Br*C₂₃H₂₄P
• Molecular Weight: 411.31
• Mol File: 7333-52-0.mol
• Article Data: 8

Chemical Properties

• Melting Point: 262-266°C
• Appearance: /
• Sensitive: Hygroscopic
• BRN: 3580193
• CAS DataBase Reference: CYCLOPENTYLTRIPHENYLPHOSPHONIUM BROMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: CYCLOPENTYLTRIPHENYLPHOSPHONIUM BROMIDE(7333-52-0)
• EPA Substance Registry System: CYCLOPENTYLTRIPHENYLPHOSPHONIUM BROMIDE(7333-52-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 7333-52-0(Hazardous Substances Data)

Usage

General Description

Cyclopentyltriphenylphosphonium bromide is a chemical compound with the formula (C6H5)3P(C5H9)Br. It is a quaternary ammonium salt that is commonly used as a phase transfer catalyst in organic synthesis. It is a white crystalline solid that is soluble in polar organic solvents. CYCLOPENTYLTRIPHENYLPHOSPHONIUM BROMIDE is known for its ability to facilitate reactions between immiscible reactants by transferring one reactant from one phase to another. It has been used in a variety of chemical reactions, including Williamson ether synthesis, nucleophilic substitution, and alkylation reactions. It is also used in the synthesis of pharmaceuticals and other fine chemicals.

InChI:InChI=1/C23H24P.BrH/c1-4-12-20(13-5-1)24(23-18-10-11-19-23,21-14-6-2-7-15-21)22-16-8-3-9-17-22;/h1-9,12-17,23H,10-11,18-19H2;1H/q+1;/p-1

Upstream product

• 137-43-9 Cyclopentyl bromide 
• 603-35-0 triphenylphosphine 
• 4399-47-7 Bromocyclobutane 
• 110-52-1 1,4-dibromo-butane 
• 19493-09-5 Methylenetriphenylphosphorane 

Downstream Products

• 111653-80-6 o-(1,3-dioxolan-2-yl)benzylidenecyclopentane 
• 1026382-20-6 4-[3-Cyclopentylidenemethyl-6-(2-ethyl-butylcarbamoyl)-indol-1-ylmethyl]-3-methoxy-benzoic acid methyl ester 
• 21482-00-8 Cyclopentylidene-triphenyl-λ⁵-phosphane 
• 530144-92-4 1-(benzyloxy)-3-(cyclopentylidenemethyl)benzene 
• 85477-46-9 2-Cyclopentyliden-2-methoxythioessigsaeure-O-methylester 
• 3878-45-3 triphenylphosphine sulfide 

Relevant articles and documents

THERAPEUTIC COMPOUNDS

The present disclosure relates to compounds of formula (I) and pharmaceutically acceptable salts thereof, and compositions and uses thereof. The compounds are useful as inhibitors of the YAP:TEAD protein:protein interaction. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various YAP:TEAD-mediated disorders, including cancer.

Synthesis of 2,3-Disubstituted Quinolines via Ketenimine or Carbodiimide Intermediates

Cyclopenta[b]quinolines and cyclohexa[b]quinolines were prepared via the reactions of α-diazo ketones with N-(2-cyclopropylidenemethylphenyl)phosphanimines and N-(2-cyclobutylidenemethylphenyl) phosphanimine, respectively. The reaction proceeds in a cascade involving ketenimine formation, 6 π-electron ring closure, and 1,3-alkyl shift. A similar approach was developed for the synthesis of dihydropyrrolo-[2,3-b]quinolines from N-(2-cyclopropylidenemethylphenyl)phosphanimines and isocyanates.

OXASPIRO [2.5] OCTANE DERIVATIVES AND ANALOGS

The invention provides oxaspiro[2.5]octane derivatives and analogs, methods for preparation thereof, intermediates thereto, pharmaceutical compositions, and uses thereof in the treatment of various disorders and conditions, such as overweight and obesity.