73341-73-8 Usage
General Description
Macbecin II is a natural product derived from the fermentation of the bacterium Actinomadura macra and is classified as a member of the ansamycin antibiotics. It exhibits potent antibacterial and antitumor activities by inhibiting the activity of heat shock protein 90 (Hsp90), which is responsible for the stabilization and functioning of various client proteins involved in cell growth and survival. Macbecin II has been found to be effective against a wide range of bacterial strains, including methicillin-resistant Staphylococcus aureus (MRSA), and has shown promise in preclinical studies for the treatment of various cancers, making it a potentially valuable therapeutic agent in the fight against microbial and neoplastic diseases. However, its clinical use is limited due to its poor solubility and potential adverse effects on the liver, highlighting the need for further research and development to improve its pharmaceutical properties and safety profile.
Check Digit Verification of cas no
The CAS Registry Mumber 73341-73-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,3,3,4 and 1 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 73341-73:
(7*7)+(6*3)+(5*3)+(4*4)+(3*1)+(2*7)+(1*3)=118
118 % 10 = 8
So 73341-73-8 is a valid CAS Registry Number.
InChI:InChI=1/C30H44N2O8/c1-16-10-9-11-17(2)29(35)32-23-15-21(33)14-22(25(23)34)27(38-7)20(5)13-24(37-6)28(39-8)19(4)12-18(3)26(16)40-30(31)36/h9-12,14-16,19-20,24,26-28,33-34H,13H2,1-8H3,(H2,31,36)(H,32,35)/b10-9+,17-11-,18-12-/t16-,19+,20-,24+,26?,27+,28-/m0/s1
