73352-74-6 Usage
Type of compound
Synthetic derivative of kanamycin A, an aminoglycoside antibiotic.
Modification
Addition of an ethylcarbamate group to the amino group at position 2 of the kanamycin A molecule.
Purpose of modification
To improve stability and pharmacokinetic properties while maintaining antibacterial activity.
Potential use
Treatment of bacterial infections, especially those caused by multidrug-resistant bacteria.
Reduced toxicity
Modified structure may lower the potential for toxicity and side effects commonly associated with aminoglycoside antibiotics.
Clinical potential
Promising candidate for clinical use due to its improved properties and reduced side effects.
Check Digit Verification of cas no
The CAS Registry Mumber 73352-74-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,3,3,5 and 2 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 73352-74:
(7*7)+(6*3)+(5*3)+(4*5)+(3*2)+(2*7)+(1*4)=126
126 % 10 = 6
So 73352-74-6 is a valid CAS Registry Number.
InChI:InChI=1/C21H41N5O13/c22-1-2-35-21(34)26-7-3-6(24)17(38-20-15(32)14(31)12(29)8(4-23)36-20)16(33)18(7)39-19-13(30)10(25)11(28)9(5-27)37-19/h6-20,27-33H,1-5,22-25H2,(H,26,34)
73352-74-6Relevant articles and documents
Semisynthetic Aminoglycoside Antibacterials. Part 10. Synthesis of Novel 1-N-Aminoalkoxycarbonyl and 1-N-Aminoalkylcarboxamido Derivatives of Sisomicin, Gentamicin B, Gentamicin C1a, and Kanamycin A
Mallams, Alan K.,Morton, James B.,Reichert, Paul
, p. 2186 - 2208 (2007/10/02)
Suitably protected derivatives of sisomicin, 5-epi-sisomicin, gentamicin B, gentamicin C1a, and kanamycin A have been converted into a series of 1-N-alkoxycarbonyl, 1-N-aminoalkoxycarbonyl, 1-N-carboxamido, 1-N-alkylcarboxamido, and 1-N-aminoal
