73372-24-4Relevant academic research and scientific papers
A catalytic approach to the metal-free reaction of epoxides with ketene silyl acetals for accessing γ-lactones
Bonollo, Simona,Ahmady, Amanollah Zarei,Petrucci, Chiara,Marrocchi, Assunta,Pizzo, Ferdinando,Vaccaro, Luigi
, p. 5721 - 5723 (2014)
The first catalytic approach to the nucleophilic addition of silyl ketene acetals 2 to epoxides 1 is reported. The defined protocol is metal-free using tetrabutylammonioum fluoride as the catalyst. It works in a very efficient manner under solvent-free co
Reaction of silyl ketene acetals with epoxides: A new method for the synthesis of γ-butanolides
Maslak, Veselin,Matovi?, Radomir,Sai?i?, Radomir N.
, p. 8957 - 8966 (2007/10/03)
Titanium tetrachloride promoted reaction of silyl ketene acetals with epoxides, followed by acidic work-up, affords butanolides in moderate/good yields. With epihalohydrins the reaction is regioselective and occurs at the less substituted end of the epoxide; the γ-haloalkyl-γ-butanolides thus obtained can be further transformed into various products. Graphical Abstract
