7338-74-1Relevant academic research and scientific papers
1,2,4-TRIAZINES DERIVATIVES, PREPARATION THEREOF AND USE THEREOF IN HUMAN THERAPEUTICS
-
Page/Page column 19-20, (2010/02/13)
The invention relates to 3,5-dioxo-(2H,4H)-1,2,4-triazine derivatives of general formulae (I or II), in which in particular: R1 represents hydrogen, a linear or branched C1-C6 alkyl or alkoxy radical, a C5-C6 cycloalkyl radical, a phenyl (C1-C2) alkyl radical or a phenyl radical;-R2 represents hydrogen, a linear or branched Cl-C7alkyl radical, or a C1-C6 alkyl radical substituted with groups such as trifluoromethyl or phenyl;- linker represents a C2-C6 alkyl chain or -(CH2)n-O- (n = 2 to 5), - R3 represents a group of general formula below for which X = O, linker can be connected to the ortho-, meta- or para-positions of the aromatic of the group R3, R4, R5, R6, R7 and R8 represent hydrogen or fluorine, R9, Rio and R11 represent hydrogen or a linear or branched Cl-C5 alkyl group, in particular R9 and Rio represent the methyl group and R11 represents hydrogen or the ethyl group.
Derivatives of 1,2,4-Triazin-5-one
Khamaev, V. Kh.,Danilov, V. A.,Khannanov, R. N.,Mazitova, A. K.
, p. 825 - 829 (2007/10/02)
3-Mercapto-1,2,4-triazin-5-ones were obtained by the reaction of thiosemicarbazide with α-keto carboxylic acids, 2-cyano-2-propanol, isatin, and 5-furfurylidenethiazolidine-2,4-dione.The first three methods gave high yields.
