73395-16-1

Basic information

• Product Name: Carbamic acid, [1-(hydroxymethyl)propyl]-, phenylmethyl ester, (R)-
• CAS NO: 73395-16-1
• Molecular Formula: C12H17NO3
• Molecular Weight: 223.272
• Mol File: 73395-16-1.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [1-(hydroxymethyl)propyl]-, phenylmethyl ester, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [1-(hydroxymethyl)propyl]-, phenylmethyl ester, (R)-(73395-16-1)
• EPA Substance Registry System: Carbamic acid, [1-(hydroxymethyl)propyl]-, phenylmethyl ester, (R)-(73395-16-1)

Safety Data

• Hazardous Substances Data: 73395-16-1(Hazardous Substances Data)

Upstream product

• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 
• 5856-63-3 (2R)-2-aminobutan-1-ol 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 950510-38-0 C₁₂H₁₆BrNO₂ 
• 73352-52-0 (2R)-N-(2-benzyloxycarbonylaminobutoxycarbonyloxy)succinimide 
• 98289-85-1 (R)-2-benzyloxycarbonylamino-1-iodobutane 
• 98289-87-3 (S)-(+)-2-benzyloxycarbonylaminobutane 
• 73352-67-7 (2R)-3,6'-bis-N-benzyloxycarbonyl-1-N-(2-benzyloxycarbonylaminobutyloxycarbonyl)gentamicin B 
• 73352-52-0 (2R)-N-(2-benzyloxycarbonylaminobutyloxycarbonyloxy)sucinimide 
• 98289-83-9 (R)-2-benzyloxycarbonylamino-1-tosyloxybutane 
• 143915-15-5 (R)-1-oxobutane-2-benzylcarbamate 

Relevant articles and documents

Highly diastereoselective addition of trimethylsilyl cyanide to chiral hydrazones in the presence of Et2AlCl

Chiral hydrazones, synthesized from (S)-1-amino-2-methoxymethylindoline and aliphatic aldehydes, reacted with trimethylsilyl cyanide in the presence of diethylaluminium chloride in CH2Cl2 at -78°C to give chiral α-hydrazinonitriles w

Carbamate derivatives of felbamate as potential anticonvulsant agents

Several monocarbamate compounds derived from felbamate were synthesized and 11 target compounds (1, 4, and 6-14) were initially evaluated in mice MES and PTZ models in our laboratory. Carbamate compounds with varying substituents on the oxygen (1-4) gave anticonvulsant activity with a wide range of ED 50 in MES test from 300 mg/kg (4) and compounds with different groups on the nitrogen (5-14) also were quite active in the range of 15 mg/kg (14) to 170.5 mg/kg (6). This suggested that the spatial limitation in the MES model seemed flexible especially on the nitrogen end. All tested compounds showed some activity against mice scPTZ test, but none had the ED50 value 50 mg/kg. Ten selected compounds (1 and 6-14) for subsequent pharmacological evaluation in NIH all gave positive mice MES activity except 8 and 9, which were unexpectedly active in rats after further evaluations. Among the compounds, 1, 8, and 9 advanced to the quantitative study and 1 and 9 provided the highest PI values, 15 and 21, respectively, in the rat oral MES test.

NOVEL BETA-LACTAM COMPOUNDS AND PROECSS FOR PRODUCING THE SAME

1. A β-lactam compound of the formula [1]; ???wherein R1 is a lower alkyl, a lower alkyl substituted by a hydroxy; R2 is a hydrogen, a lower alkyl; X is O, S, NH; m and n are 0 to 4, Y1 is a halogen, cyano, a hydroxy, an amino, a lower alkyloxy, a lower alkylamino, a carboxy, a carbamoyl, a lower alkyl, etc., Y2 is hydrogen, an alkyl, cyano, -C(R3)=NR4 (wherein R3 and R4 are hydrogen, an amino, an alkyl, etc., or R3 and R4 may combine each other together with the nitrogen atom to form a 5- to 7-membered heterocyclic group), or a pharmaceutically acceptable salt thereof, or a non-toxic ester thereof, which has an excellent antibacterial activity against Gram-positive bacteria, especially against MRSA and MRCNS.