73402-76-3Relevant academic research and scientific papers
Zinc(II)-Catalyzed Synthesis of Propargylamines by Coupling Aldimines and Ketimines with Alkynes
Shehzadi, Syeda Aaliya,Saeed, Aamer,Lemière, Filip,Maes, Bert U. W.,Abbaspour Tehrani, Kourosch
, p. 78 - 88 (2018)
A ZnII-catalyzed reaction between imines, which were derived from unactivated aldehydes or ketones and primary amines or α-amino acid esters, and terminal alkynes has led to the rapid and efficient formation of tri- and tetrasubstituted propargylamines (from aldimines and ketimines, respectively) in good to excellent yields. No additives or extra Lewis acid reagents were required for the imine-alkyne coupling reaction.
