73414-41-2

Upstream product

• 186581-53-3 diazomethane 
• 80325-88-8 8-methoxy-7-isopropyl-1,4aβ-dimethyl-3,4,4a,9,10,10a-hexahydrophenanthrene 
• 609-09-6 Diethyl ketomalonate 
• 80325-99-1 C₂₂H₃₀O₄ 
• 80865-66-3 1-((E)-6-Bromo-4-methyl-hex-3-enyl)-3-isopropyl-2-methoxy-benzene 
• 73414-37-6 2-(β-iodoethyl)butyrolactone 
• 2181-42-2 trimethylsulphonium iodide 
• 214077-12-0 (E)-2-Chloro-9-(3-isopropyl-2-methoxy-phenyl)-6-methyl-3-oxo-non-6-enoic acid ethyl ester 
• 214077-11-9 (E)-9-(3-Isopropyl-2-methoxy-phenyl)-6-methyl-3-oxo-non-6-enoic acid methyl ester 
• 263157-59-1 1-Isopropyl-2-methoxymethoxy-3-(4-methyl-pent-3-enyl)-benzene 
• 263157-65-9 1-((E)-5-Bromo-4-methyl-pent-3-enyl)-3-isopropyl-2-methoxy-benzene 
• 214077-10-8 (E)-5-(3-Isopropyl-2-methoxy-phenyl)-2-methyl-pent-2-en-1-ol 
• 263157-61-5 1-Isopropyl-2-methoxy-3-(4-methyl-pent-3-enyl)-benzene 
• 74931-59-2 1-isopropyl-2-methoxymethyloxybenzene 

Relevant academic research and scientific papers

Diastereoselective formal total synthesis of (±)-triptolide via a novel cationic cyclization of 2-alkenyl-1,3-dithiolane

A concise and diastereoselective formal total synthesis of triptolide, a natural product with a wide range of biological properties, is described. The key reaction is an unprecedented 6-endo-Trig cationic cyclization of a 2-alkenyl-1,3-dithiolane precursor induced by TMSOTf as Lewis acid.

Total Synthesis of Racemic Triptolide and Triptonide

The total synthesis of (+/-)-triptolide (1) and (+/-)-triptonide (3) from tetralone 7 in 15 and 16 steps, respectively, is described.