7342-42-9

Usage

Uses

Used in Pharmaceutical Industry:
2-Thienylacetic acid is used as a key intermediate in the synthesis of various pharmaceuticals due to its unique chemical structure and properties. It contributes to the production of a wide range of bioactive molecules, enhancing the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Thienylacetic acid serves as an essential building block for the synthesis of agrochemicals. Its incorporation into these compounds aids in the development of effective pesticides, herbicides, and other agricultural chemicals, promoting sustainable agricultural practices.
Used in Organic Synthesis:
2-Thienylacetic acid is utilized as a versatile building block in organic synthesis for the creation of various functional groups. Its ability to form different chemical entities makes it an important intermediate in the synthesis of complex organic compounds, contributing to the advancement of chemical research and development.
Used in Medicinal Chemistry Research:
Owing to its potential anti-inflammatory and antimicrobial properties, 2-Thienylacetic acid is a subject of interest in the field of medicinal chemistry. Researchers explore its applications in the development of novel therapeutic agents, particularly for the treatment of inflammatory and infectious diseases.

InChI:InChI=1/C6H6O2S2/c7-5(8)4-10-6-2-1-3-9-6/h1-3H,4H2,(H,7,8)

Upstream product

• 7774-74-5 Thiophene-2-thiol 
• 79-08-3 bromoacetic acid 
• 82187-66-4 ethyl 2-(thiophen-2-sulfanyl)acetate 
• 79-11-8 chloroacetic acid 
• 188290-36-0 thiophene 

Downstream Products

• 82187-66-4 ethyl 2-(thiophen-2-sulfanyl)acetate 

Relevant academic research and scientific papers

Synthesis of thioether andrographolide derivatives and their inhibitory effect against cancer cells

A series of novel thioether andrographolide derivatives were synthesized by incorporating various aromatic (or heteroaromatic) substituents into C-12 or 14-OH. A total of 38 andrographolide derivatives were prepared and evaluated for their in vitro inhibi

SYNTHESIS OF FUNCTIONALLY SUBSTITUTED DERIVATIVES OF 2-THIOPHENETHIOL

The reactions of 2-thiophenethiol with compounds containing mobile halogen atoms and multiple bonds were studied.As a result a series of functionally substituted derivatives of 2-thiophenethiol were synthesized.

Electrophilic Aromatic Substitution. Part 31. Partial Rate Factors for Detritiation of Thienothiophen and Thienothiophen: Weak Hydrogen Bonding to Sulphur in Trifluoroacetic Acid

Thienothiophen (I) and thienothiophen (II), specifically labelled with tritium in each position have been prepared, and their rates of protiodetritiation measured along with that for thiophen in either pure trifluoroacetic acid, or mixtures of trifluoroacetic acid and acetic acid, all at 70 deg C.The dependence of exchange rate coefficients upon acid composition indicates that the ring sulphur is hydrogen bonded, and to an extent which depends upon the number of sulphur atoms in the heterocycle.Partial rate factors for detritiation of the non-hydrogen-bonded compounds are calculated as follows (position and compound in parentheses): 7.18E8 ; 6.83E8 ; 9.75E7 (2-thiophen); 7.59E5 ; 5.54E5 ; 7.84E4 (3-thiophen), the corresponding ?+-values being -1.012, -1.010, -0.913, -0.672, -0.656, and -0.560.The results, taken along with those for acylation and chlorination show that (II) is more polarisable than (I), so that these compounds, like all other ?-excessive heterocycles previously examined, are unsuitable for rigorous application of the Extended Selectivity Relationship.Annelation of thiophen by thiophen produces a comparable change in reactivities of the α- and β-positions in contrast to annelation by benzene, where the high resonance energy of benzene plays a crucial role in raising the reactivity of the β-position, relative to that of the α-position.