7342-42-9

Basic information

• Product Name: 2-Thienylaceticacid
• Synonyms: Nsc74725;2-(Thiophen-2-ylthio)acetic acid
• CAS NO: 7342-42-9
• Molecular Formula: C6H6 O2 S2
• Molecular Weight: 174.2406
• Mol File: 7342-42-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 331.3°Cat760mmHg
• Flash Point: 154.2°C
• Appearance: /
• Density: 1.43g/cm³
• Vapor Pressure: 6.28E-05mmHg at 25°C
• Refractive Index: 1.639
• CAS DataBase Reference: 2-Thienylaceticacid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Thienylaceticacid(7342-42-9)
• EPA Substance Registry System: 2-Thienylaceticacid(7342-42-9)

Safety Data

• Hazardous Substances Data: 7342-42-9(Hazardous Substances Data)

Usage

General Description

2-Thienylacetic acid is a chemical compound with the formula C6H6O2S. It is a carboxylic acid derivative with a thienyl group attached to the acetic acid molecule. 2-Thienylaceticacid is commonly used in the synthesis of pharmaceuticals and agrochemicals. Its unique chemical structure and properties make it valuable for the production of a wide range of bioactive molecules. It can also be used as a building block in organic synthesis for the creation of various functional groups, making it an important intermediate in the pharmaceutical and chemical industries. 2-Thienylacetic acid is also known for its potential anti-inflammatory and antimicrobial properties, making it a subject of interest in the field of medicinal chemistry.

InChI:InChI=1/C6H6O2S2/c7-5(8)4-10-6-2-1-3-9-6/h1-3H,4H2,(H,7,8)

Upstream product

• 7774-74-5 Thiophene-2-thiol 
• 79-08-3 bromoacetic acid 
• 79-11-8 chloroacetic acid 
• 82187-66-4 ethyl 2-(thiophen-2-sulfanyl)acetate 
• 188290-36-0 thiophene 

Downstream Products

• 82187-66-4 ethyl 2-(thiophen-2-sulfanyl)acetate 

Relevant articles and documents

Synthesis of thioether andrographolide derivatives and their inhibitory effect against cancer cells

A series of novel thioether andrographolide derivatives were synthesized by incorporating various aromatic (or heteroaromatic) substituents into C-12 or 14-OH. A total of 38 andrographolide derivatives were prepared and evaluated for their in vitro inhibi

Electrophilic Aromatic Substitution. Part 31. Partial Rate Factors for Detritiation of Thienothiophen and Thienothiophen: Weak Hydrogen Bonding to Sulphur in Trifluoroacetic Acid

Thienothiophen (I) and thienothiophen (II), specifically labelled with tritium in each position have been prepared, and their rates of protiodetritiation measured along with that for thiophen in either pure trifluoroacetic acid, or mixtures of trifluoroacetic acid and acetic acid, all at 70 deg C.The dependence of exchange rate coefficients upon acid composition indicates that the ring sulphur is hydrogen bonded, and to an extent which depends upon the number of sulphur atoms in the heterocycle.Partial rate factors for detritiation of the non-hydrogen-bonded compounds are calculated as follows (position and compound in parentheses): 7.18E8 ; 6.83E8 ; 9.75E7 (2-thiophen); 7.59E5 ; 5.54E5 ; 7.84E4 (3-thiophen), the corresponding ?+-values being -1.012, -1.010, -0.913, -0.672, -0.656, and -0.560.The results, taken along with those for acylation and chlorination show that (II) is more polarisable than (I), so that these compounds, like all other ?-excessive heterocycles previously examined, are unsuitable for rigorous application of the Extended Selectivity Relationship.Annelation of thiophen by thiophen produces a comparable change in reactivities of the α- and β-positions in contrast to annelation by benzene, where the high resonance energy of benzene plays a crucial role in raising the reactivity of the β-position, relative to that of the α-position.