7343-33-1

Usage

Uses

Used in Coordination Chemistry:
3-Bromo-1H-1,2,4-triazole is used as a ligand for transition metals to create coordination complexes. Its ability to form stable complexes with metals is valuable in various chemical and material science applications, such as catalysts, sensors, and pharmaceuticals.
Used in Synthetic Reactions:
3-Bromo-1H-1,2,4-triazole is part of the 1,2,4-triazole family, which has the ability to accept and transfer acyl groups in synthetic reactions. This property makes it a useful catalyst for the synthesis of esters, such as 2,2-Dimethylacetoacetic Acid Ethyl Ester (D460776). Its catalytic activity contributes to the efficiency and selectivity of esterification reactions in the chemical industry.

InChI:InChI=1/C2H2BrN3/c3-2-4-1-5-6-2/h1H,(H,4,5,6)

Upstream product

• 7411-23-6 3,5-dibromotriazole 
• 61-82-5 3⁽⁵⁾-amino-1,2,4-triazole 
• 24807-55-4 3-nitro-1,2,4-triazole 

Downstream Products

• 35523-67-2 4,7-dihydro-5-methyl-7-oxo[1,2,4]triazolo[1,5-a]pyrimidine 
• 18377-89-4 3-Morpholino-1,2,4-triazol 
• 76279-98-6 3-nitro-5-(3-bromo-1,2,4-triazol-1-yl)-1,2,4-triazol 
• 105958-58-5 methyl 3-(3-nitro-1H-1,2,4-triazol-1-yl)propanoate 
• 550363-95-6 2-(3-bromo-1H-1,2,4-triazol-1-yl)pyridine 
• 623577-63-9 1-(4-fluorophenyl)-3-bromo-1,2,4-1H-triazole 
• 288-88-0 1,2,4-Triazole 
• 64907-55-7 5-bromo-1-ethyl-1H-1,2,4-triazole 

Relevant academic research and scientific papers

PYRAZOLE DERIVATIVES AS JAK INHIBITORS

New pyrazole derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).

Novel orally bioavailable γ-secretase inhibitors with excellent in vivo activity

The development of potent γ-secretase inhibitors having substituted heterocycles attached to a benzobicyclo[4.2.1]nonane core is described. This work led to the identification of [6S,9R,11R]-2′,3′,4′,5, 5′,6,7,8,9,10-decahydro-2-(5-(4-fluorophenyl)-1-methylpyrazol-3-yl) -5′-(2,2,2-trifluoroethyl)spiro[6,9-methanobenzocyclooctene-11, 3′-[1,2,5]thiadiazole] 1′,1′-dioxide (16), which has excellent in vitro potency (0.06 nM) and which reduced amyloid-β in APP-YAC mice with an ED50 of 1 mg/kg (po). 16 had a good pharmacokinetic profile in three preclinical species.

Discovery of novel heteroarylazoles that are metabotropic glutamate subtype 5 receptor antagonists with anxiolytic activity

The highly potent, selective, and brain-penetrant metabotropic glutamate subtype 5 (mGlu5) receptor antagonists 3-(5-pyridin-2-yl-2H-tetrazol-2-yl) benzonitrile (47) and 3-fluoro-5-(5-pyridin-2-yl-2H-tetrazol-2-yl)benzonitrile (48) are reported. Compound 47 is active in the rat fear-potentiated startle (FPS) model of anxiety with ED50 = 5.4 mg/kg (po) when dosed acutely. In this model the anxiolytic effects of 47 rapidly tolerate on repeated dosing.

HETEROARYL SUBSTITUTED SPIROCYCLIC SULFAMIDES FOR INHIBITION OF GAMMA SECRETASE

Compounds of formula I are disclosed: in which X is a 5-membered heteroaryl ring and R is as defined herein. The compounds are inhibitors of the processing of APP by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.

Micelle Activated Reactions I. Micelle Activated Iodination and Partial Dehalogenation of Pyrazoles and 1,2,4-Triazoles

A method is described to iodinate pyrazole, substituted pyrazoles or 1,2,4-triazole with iodine or iodine chloride in aqueous alkaline in the presence of an anionic surfactant. 4-Iodo- (2a), 4-iodo-3(5)-methyl- (2b), 3(5),4-diiodo- (3a), 3(5),4-diiodo-5(3)-methyl- (3b), and 3,4,5-triiodo-pyrazole (3d) as soon as 4-iodo-pyrazole-3(5)-carboxylic acid (2c), and 3(5)-iodo-1,2,4-triazole (5) were prepared.Anhydrous hydrogen fluoride or triethylamine trishydrofluoride were found to be a suitable agent to effect a regioselective partial dehalogenation of 3b, 3d and 3,5-dibromo-1,2,4-triazole (7).We prepared 3(5)-iodo-5(3)-methyl-pyrazole (6b), 3,5-diiodo-pyrazole (6d) and 3(5)-bromo-1,2,4-triazole (8) on this way.