73434-55-6

Upstream product

• 557-20-0 diethylzinc 
• 1571-08-0 methyl 4-formylbenzoate 
• 82248-43-9 B(OH)2CHCH₃C₂H₅ 
• 619-44-3 methyl 4-iodobenzoate 
• 619-42-1 4-methoxycarbonylphenyl bromide 
• 73434-45-4 Methyl 3-(4-(1-Methylpropyl)benzoyl)propionate 
• 186581-53-3 diazomethane 
• 73434-53-4 Ethyl 4-Ethoxy-4-<4-(1-methylpropyl)phenyl>-3-butenoate 

Downstream Products

• 73434-56-7 4-(1-Methylpropyl)benzoic acid 

Relevant academic research and scientific papers

Chiral Lithium Amido Zincates for Enantioselective 1,2-Additions: Auto-assembling Reagents Involving a Fully Recyclable Ligand

A methodology consisting in carrying out enantioselective nucleophilic 1,2-additions (ee values up to 97 %) from cheap, easily accessible, and never described before, chiral lithium amido zincates is presented. These multicomponent reactants auto-assemble when mixing, in a 1:1 ratio, a homoleptic diorganozinc (R2Zn) with a chiral lithium amide (CLA). The latter, obtained after a single reductive amination, plays the role of the chiral inductor and is fully recoverable thanks to a simple acid–base wash, allowing being recycled and re-use without loss of stereochemical information.

CROSS-COUPLING OF UNACTIVATED SECONDARY BORONIC ACIDS

Provided are methods for site- and stereo-retentive cross-couplings with unactivated secondary boronic acids, particularly useful in building block-based approach for small molecule synthesis. Also provided is a method of forming an air-stable chiral secondary boronic acid.

Stereochemical Course of the Haworth-Type Synthesis of Optically Active 2-(1-Methylpropyl)naphthalene

The preparation of (S)-2-(1-methylpropyl)naphthalene has been accomplished by starting from (S)-(1-methylpropyl)benzene with detectable racemization.The partially unstereospecific steps have been distinguished by evaluating the optical purity of key intermediates through chemical correlations with known optically active compounds.